Fetal heart size measurements as new predictors of homozygous -thalassemia-1 in mid-pregnancy

被引：16

作者：

Li, Xinyan ^{[1
]}

Qiu, Xiaoxia ^{[1
]}

Huang, Huan ^{[1
]}

Zhao, Yili ^{[2
]}

Li, Xueqin ^{[1
]}

Li, Meng ^{[1
]}

Tian, Xiaoxian ^{[1
]}

机构：

[1] Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Dept Ultrasonog, 225 Xinyang Rd, Nanning 530003, Guangxi, Peoples R China

[2] Eastern Virginia Med Sch, Dept Obstet & Gynecol, Norfolk, VA 23501 USA

来源：

CONGENITAL HEART DISEASE | 2018年 / 13卷 / 02期

关键词：

fetal echocardiography; heart size; homozygous; -thalassemia-1; midpregnancy; prenatal diagnosis; z-scores; CARDIOTHORACIC RATIO; SOUTHERN CHINA; DISEASE; RANGES;

D O I：

10.1111/chd.12568

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveTo evaluate the efficacy of using fetal heart size measurements derived from axial echocardiography to predict homozygous -thalassemia-1. DesignProspective diagnostic study. SettingThe carrier rate of -thalassemia-1 (-/) in China's Guangxi Zhuang Autonomous Region is approximately 15%. If both parents are carriers, the risk of homozygous -thalassemia-1 in one pregnancy is 25%. PatientsSingleton mid-pregnancies at risk of homozygous -thalassemia-1 were enrolled. Outcome MeasuresFetal heart measurements, including heart diameter (HD), heart length (HL), heart circumference (HC), and heart area (HA), were measured. The z-scores for these heart parameters were then calculated separately based on previously constructed z-score models. Finally, the accuracy of these predictive variables was analyzed and compared to that achieved by cardiothoracic ratio (CTR) using a receiver operating characteristic (ROC) curves analysis. ResultsA total of 214 singleton pregnancies were recruited. The discriminatory power of HA and HD z-scores was better (z-test P< .01) while that of HC and HL z-scores was comparable to (z-test P>.05) that of CTR. HD combined with HA z-scores had the highest sensitivity (100%), and the specificity of HD and/or HA z-scores was 100%. ConclusionFetal heart size measurements are novel, effective and noninvasive predictors of homozygosity for -thalassemia-1 in mid-pregnancy. The discriminatory power of HD and HA z-scores was better than while that of HC and HL z-scores was comparable to that of CTR. Further investigation is needed to understand the effectiveness of these predictors.

引用

页码：282 / 287

页数：6

共 11 条

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