Impact of autologous stem cell transplantation on survival outcomes in patients with peripheral T cell lymphoma

被引：1

作者：

Guren, Ceren Uzunoglu ^{[1
,4
]}

Toptas, Tayfur ^{[1
]}

Mehtap, Ozgur ^{[2
]}

Yilmaz, Guven ^{[3
]}

Polat, Gokcen ^{[2
]}

Oruc, Ozen ^{[1
]}

Ercan, Tarik ^{[1
]}

Arikan, Fatma ^{[1
]}

Yilmaz, Fergun ^{[1
]}

Atagunduz, Isik Kaygusuz ^{[1
]}

Tuglular, Tulin ^{[1
]}

机构：

[1] Marmara Univ Hosp, Dept Hematol, Istanbul, Turkey

[2] Kocaeli Univ Hosp, Dept Hematol, Kocaeli, Turkey

[3] Lutfi Kirdar Training & Res Hosp, Dept Hematol, Istanbul, Turkey

[4] Univ Hosp, Dept Hematol, Istanbul 34899, Turkey

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2022年 / 61卷 / 06期

关键词：

Peripheral T cell lymphoma; Autologous stem cell transplantation; Prognosis of peripheral T cell lymphoma; NON-HODGKIN-LYMPHOMA; PROGNOSTIC-FACTORS; CONSOLIDATION; PTCL;

D O I：

10.1016/j.transci.2022.103514

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Data about the timing of autologous stem cell transplantation (ASCT) in peripheral T cell lymphoma (PTCL) are conflicting. We aimed to investigate the impact of the sequence of ASCT on the survival outcomes in patients with PTCL. Analyzes were performed retrospectively in a total of 81 patients, 16 of whom underwent upfront ASCT and 12 received salvage ASCT. In univariate analysis, upfront ASCT reduced the risk of progression and death by 77% (Hazard ratio (HR): 0.23, 95% confidence interval (CI): 0.09-0.60) (p = 0.003) and by 84% (HR: 0.16, 95% CI: 0.5-0.55) (p = 0.003), respectively. However, in multivariate analysis, only salvage ASCT predicted a more favorable progression-free and overall survival (HR: 0.17, 95% CI: 0.06-0.48, p = 0.001 and HR: 0.20, %95 GA: 0.06-0.62, p = 0.005, respectively). In conclusion, regardless of first-line therapy, patients have more favorable outcomes if they receive salvage ASCT. Upfront ASCT does not add clinically significant benefit to survival outcomes.

引用

页数：6

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