Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) as Markers of Insulin Resistance and Metabolic Associated Disturbances in Young Argentine Women with Polycystic Ovary Syndrome

被引:52
作者
Abruzzese, Giselle A. [1 ]
Cerrrone, Gloria E. [2 ,3 ]
Gamez, Juan M. [4 ]
Graffigna, Mabel N. [4 ]
Belli, Susana [4 ]
Lioy, Gustavo [5 ]
Mormandi, Eduardo [4 ]
Otero, Patricia [4 ]
Levalle, Oscar A. [4 ]
Motta, Alicia B. [1 ]
机构
[1] Univ Buenos Aires, CONICET, Fac Med, Ctr Estudios Farmacol & Bot CEFYBO,Lab Fisiopatol, Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Farm & Bioquim, Dept Microbiol Inmunol & Biotecnol, Catedra Genet, Buenos Aires, DF, Argentina
[3] CONICET UBA, Inst Inmunol Genet & Metab, Buenos Aires, DF, Argentina
[4] Hosp Gen Agudos Carlos G Durand, Div Endocrinol, Buenos Aires, DF, Argentina
[5] Hosp Nacl Prof Alejandro Posadas, Div Ginecol, Buenos Aires, Buenos Aires, Argentina
关键词
hyperandrogenism; polycystic ovary syndrome; insulin resistance; cardiovascular risk; metabolic syndrome; GLUCOSE CLAMP TECHNIQUE; CARDIOMETABOLIC RISK; ENDOCRINE CHARACTERISTICS; CARDIOVASCULAR RISK; DYSFUNCTION; PHENOTYPES; OBESITY; MEN;
D O I
10.1055/s-0042-113463
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Polycystic ovary syndrome (PCOS) is an endocrine disorder. PCOS women are at high risk of developing insulin resistance (IR) and cardiovascular disorders since young age. We aimed to study the reliability of lipid accumulation product (LAP) and visceral adiposity index (VAI) as markers of metabolic disturbances (MD) associated with IR in young reproductive aged PCOS patients. We also evaluated the association between LAP and VAI and the presence of hyperandrogenism. In a cross-sectional study, 110 PCOS patients and 88 control women (18-35 years old) were recruited. PCOS patients were divided into 2 groups, as hyperandrogenic and non-hyperandrogenic considering the signs of hyperandrogenism (clinical or biochemical). Anthropometric measurements were taken and blood samples collected. Metabolic and anthropometric characteristics and their association with IR and associated MD were evaluated and LAP and VAI were calculated. LAP and VAI were compared with TC/HDL-c and TG/HDL-c to define the best markers of MD in this population. Independently of the phenotype, young PCOS patients showed high IR and dyslipidemia. Both LAP and VAI showed to be more effective markers to assess MD and IR in these young women than TG/HDL-c or TC/HDL-c [cut-off values: LAP: 18.24 (sensitivity: 81.43 % specificity: 73.49 %), positive predictive value (PPV): 75.0 %, negative predictive value (NPV): 77.27 %, VAI: 2.19 (sensitivity: 81.16 % specificity: 72.15 % PPV: 74.65 % NPV: 72.22 %)]. LAP and VAI are representative markers to assess MD associated with IR in young PCOS patients. All PCOS patients, independently of their androgenic condition, showed high metabolic risk.
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页码:23 / 29
页数:7
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