Nanographene Oxide-Hyaluronic Acid Conjugate for Photothermal Ablation Therapy of Skin Cancer

被引：197

作者：

Jung, Ho Sang ^{[1
]}

Kong, Won Ho ^{[1
]}

Sung, Dong Kyung ^{[2
]}

Lee, Min-Young ^{[1
]}

Beack, Song Eun ^{[1
]}

Keum, Do Hee ^{[1
]}

Kim, Ki Su ^{[3
,4
]}

Yun, Seok Hyun ^{[3
,4
]}

Hahn, Sei Kwang ^{[1
,3
,4
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, Dept Mat Sci & Engn, Pohang 790784, Kyungbuk, South Korea

[2] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pediat, Seoul 135710, South Korea

[3] Harvard Univ, Sch Med, Dept Dermatol, Wellman Ctr Photomed, Cambridge, MA 02139 USA

[4] Massachusetts Gen Hosp, Cambridge, MA 02139 USA

来源：

ACS NANO | 2014年 / 8卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

nanographene oxide; hyaluronic acid; photothermal therapy; skin cancer; GRAPHENE OXIDE; DELIVERY; APOPTOSIS; COMPLEX;

D O I：

10.1021/nn405383a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Melanoma skin cancer is one of the most dangerous skin cancers and the main cause of skin-cancer-related mortality. Hyaluronic acid (HA) has been used as an effective transdermal delivery carrier of chemical drugs and biopharmaceuticals. In this work, a nanographene oxide-HA conjugate (NGO-HA) was synthesized for photothermal ablation therapy of melanoma skin cancer using a near-infrared (NIR) laser. Confocal microscopy and ex vivo bioimaging clearly visualized the remarkable transdermal delivery of NGO-HA to tumor tissues in the skin of mice, which might be ascribed to highly expressed HA receptors and relatively leaky structures around tumor tissues, enabling the enhanced permeation and retention of nanoparticles. The NIR irradiation resulted in complete ablation of tumor tissues with no recurrence of tumorigenesis. The antitumor effect was confirmed by ELISA for caspase-3 activity and histological and immunohistochemical analyses with TUNEL assay for tumor apoptosis. Taken together, we could confirm the feasibility of transdermal NGO-HA for photothermal ablation therapy of melanoma skin cancers.

引用

页码：260 / 268

页数：9

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