The prognostic significance of early remission of positive symptoms in first treated psychosis

被引：12
作者：
Norman, Ross M. G. [1 ,2 ]
Manchanda, Rahul [1 ,2 ]
Windell, Deborah [2 ]
机构：
[1] Univ Western Ontario, Dept Psychiat, London Hlth Sci Ctr, London, ON N6A 5W9, Canada
[2] London Hlth Sci Ctr, Prevent & Early Intervent Program Psychoses PEPP, London, ON N6A 5W9, Canada
来源：
PSYCHIATRY RESEARCH | 2014年 / 218卷 / 1-2期
关键词：
Schizophrenia; Outcomes; Prognosis; Functioning; Employment; Disability; 1ST-EPISODE PSYCHOSIS; ANTIPSYCHOTIC MEDICATION; UNTREATED PSYCHOSIS; TREATMENT RESPONSE; SCHIZOPHRENIA; DURATION; LIFE; PREDICTORS; RECOVERY; CRITERIA;
D O I：
10.1016/j.psychres.2014.04.006
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
We examine the relationship between achieving remission of positive symptoms within 3 months in first episode psychosis and outcomes 5 years later. Time to remission of positive symptoms, other early characteristics and 5 year outcomes were assessed in a prospective study of 132 patients being treated for the first time for a psychotic disorder. Just under 60% of patients showed remission of positive symptoms within 3 months. In comparison to later remitters, they showed lower levels of positive symptoms, greater likelihood of competitive employment and less likelihood of collecting a disability pension at 5 years. Earlier remission of positive symptoms may have prognostic significance for longer term outcomes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：44 / 47
页数：4
相关论文
共 50 条
  • [31] Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort
    Gonzalez-Valderrama, Alfonso
    Paz Castaneda, Carmen
    Mena, Cristian
    Undurraga, Juan
    Mondaca, Pilar
    Yanez, Matias
    Bedregal, Paula
    Nachar, Ruben
    EARLY INTERVENTION IN PSYCHIATRY, 2017, 11 (01) : 77 - 82
  • [32] Perspective on medication decisions following remission from first-episode psychosis
    Hui, Christy L. M.
    Lam, Bertha S. T.
    Lee, Edwin H. M.
    Chan, Sherry K. W.
    Chang, W. C.
    Suen, Y. N.
    Chen, Eric Y. H.
    SCHIZOPHRENIA RESEARCH, 2020, 225 : 82 - 89
  • [33] The role of cognitive control in the positive symptoms of psychosis
    Horne, Charlotte M.
    Sahni, Angad
    Pang, Sze W.
    Vanes, Lucy D.
    Szentgyorgyi, Timea
    Averbeck, Bruno
    Moran, Rosalyn J.
    Shergill, Sukhwinder S.
    NEUROIMAGE-CLINICAL, 2022, 34
  • [34] Pathways to functional outcomes following a first episode of psychosis: The roles of premorbid adjustment, verbal memory and symptom remission
    Jordan, Gerald
    Veru, Franz
    Lepage, Martin
    Joober, Ridha
    Malla, Ashok
    Iyer, Srividya N.
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2018, 52 (08) : 793 - 803
  • [35] Rates and predictors of 18-months remission in an epidemiological cohort of 661 patients with first-episode psychosis
    Conus, Philippe
    Cotton, Sue
    Schimmelmann, Benno G.
    McGorry, Patrick D.
    Lambert, Martin
    SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, 2017, 52 (09) : 1089 - 1099
  • [36] Metacognitive functioning predicts positive and negative symptoms over 12 months in first episode psychosis
    McLeod, Hamish J.
    Gumley, Andrew I.
    MacBeth, Angus
    Schwannauer, Matthias
    Lysaker, Paul H.
    JOURNAL OF PSYCHIATRIC RESEARCH, 2014, 54 : 109 - 115
  • [37] Which came first, delusions or hallucinations? An exploration of clinical differences among patients with first-episode psychosis based on patterns of emergence of positive symptoms
    Compton, Michael T.
    Potts, Amy A.
    Wan, Claire Ramsay
    Ionescu, Dawn Flosnik
    PSYCHIATRY RESEARCH, 2012, 200 (2-3) : 702 - 707
  • [38] The prognostic significance of subsyndromal symptoms emerging after remission of late-life depression
    Kiosses, D. N.
    Alexopoulos, G. S.
    PSYCHOLOGICAL MEDICINE, 2013, 43 (02) : 341 - 350
  • [39] Outcomes following first-episode psychosis - Why we should intervene early in all ages, not only in youth
    Lappin, Julia M.
    Heslin, Margaret
    Jones, Peter B.
    Doody, Gillian A.
    Reininghaus, Ulrich A.
    Demjaha, Arsime
    Croudace, Timothy
    Jamieson-Craig, Thomas
    Donoghue, Kim
    Lomas, Ben
    Fearon, Paul
    Murray, Robin M.
    Dazzan, Paola
    Morgan, Craig
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2016, 50 (11) : 1055 - 1063
  • [40] The iHOPE-20 study: Relationships between and prospective predictors of remission, clinical recovery, personal recovery and resilience 20 years on from a first episode psychosis
    O'Keeffe, Donal
    Hannigan, Ailish
    Doyle, Roisin
    Kinsella, Anthony
    Sheridan, Ann
    Kelly, Aine
    Madigan, Kevin
    Lawlor, Elizabeth
    Clarke, Mary
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2019, 53 (11) : 1080 - 1092
12345