Ca2+/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone

被引:25
作者
Rattan, Satish [1 ]
机构
[1] Thomas Jefferson Univ, Dept Med, Div Gastroenterol & Hepatol, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2017年 / 312卷 / 01期
关键词
SIGNAL-TRANSDUCTION PATHWAYS; LIGHT-CHAIN PHOSPHORYLATION; LOWER ESOPHAGEAL SPHINCTER; MYOSIN PHOSPHATASE; RHO-KINASE; BASAL TONE; MUSCARINIC RECEPTORS; CONTRACTION; SUBUNIT; PROTEIN;
D O I
10.1152/ajpgi.00370.2016
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
[No abstract available]
引用
收藏
页码:G63 / G66
页数:4
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共 41 条
  • [11] PHASIC AND TONIC CONTRACTION PROCESSES IN THE GASTROINTESTINAL-TRACT
    GOLENHOFEN, K
    MANDREK, K
    [J]. DIGESTIVE DISEASES, 1991, 9 (06) : 341 - 346
  • [12] GONG MC, 1992, J BIOL CHEM, V267, P14662
  • [13] The myosin phosphatase targeting protein (MYPT) family: A regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ
    Grassie, Michael E.
    Moffat, Lori D.
    Walsh, Michael P.
    MacDonald, Justin A.
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2011, 510 (02) : 147 - 159
  • [14] Signal-transduction pathways that regulate smooth muscle function - I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles
    Harnett, KM
    Cao, WB
    Biancani, P
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 288 (03): : G407 - G416
  • [15] Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice
    He, Wei-Qi
    Peng, Ya-Jing
    Zhang, Wen-Cheng
    Lv, Ning
    Tang, Jing
    Chen, Chen
    Zhang, Cheng-Hai
    Gao, Song
    Chen, Hua-Qun
    Zhi, Gang
    Feil, Robert
    Kamm, Kristine E.
    Stull, James T.
    Gao, Xiang
    Zhu, Min-Sheng
    [J]. GASTROENTEROLOGY, 2008, 135 (02) : 610 - 620
  • [16] Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1
    He, Wei-Qi
    Qiao, Yan-Ning
    Peng, Ya-Jing
    Zha, Juan-Min
    Zhang, Cheng-Hai
    Chen, Chen
    Chen, Cai-Ping
    Wang, Pei
    Yang, Xiao
    Li, Chao-Jun
    Kamm, Kristine E.
    Stull, James T.
    Zhu, Min-Sheng
    [J]. GASTROENTEROLOGY, 2013, 144 (07) : 1456 - U233
  • [17] Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors
    Huang, J
    Zhou, HP
    Mahavadi, S
    Sriwai, W
    Lyall, V
    Murthy, KS
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 288 (01): : G23 - G31
  • [18] Myosin phosphatase: Structure, regulation and function
    Ito, M
    Nakano, T
    Erdodi, F
    Hartshorne, DJ
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 259 (1-2) : 197 - 209
  • [19] Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle
    Kitazawa, T
    Eto, M
    Woodsome, TP
    Khalequzzaman, M
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2003, 546 (03): : 879 - 889
  • [20] Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase
    Koyama, M
    Ito, M
    Feng, JH
    Seko, T
    Shiraki, K
    Takase, K
    Hartshorne, DJ
    Nakano, T
    [J]. FEBS LETTERS, 2000, 475 (03) : 197 - 200