Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes

被引：134
|
作者：
Nadon, CA [1 ]
Bowen, BM [1 ]
Wiedmann, M [1 ]
Boor, KJ [1 ]
机构：
[1] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA
来源：
INFECTION AND IMMUNITY | 2002年 / 70卷 / 07期
关键词：
D O I：
10.1128/IAI.70.7.3948-3952.2002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp(1) and prfAp(2)) or from the upstream plcA promoter. We demonstrate that prfAp(2) is a functional sigma(B)-dependent promoter and that a sigB deletion mutation affects the virulence phenotype of L. monocytogenes. Thus, the alternative sigma factor sigma(B) contributes to virulence in L. monocytogenes.
引用
收藏
页码：3948 / 3952
页数：5
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