Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes

被引：134

作者：

Nadon, CA ^{[1
]}

Bowen, BM ^{[1
]}

Wiedmann, M ^{[1
]}

Boor, KJ ^{[1
]}

机构：

[1] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 07期

关键词：

D O I：

10.1128/IAI.70.7.3948-3952.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp(1) and prfAp(2)) or from the upstream plcA promoter. We demonstrate that prfAp(2) is a functional sigma(B)-dependent promoter and that a sigB deletion mutation affects the virulence phenotype of L. monocytogenes. Thus, the alternative sigma factor sigma(B) contributes to virulence in L. monocytogenes.

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页码：3948 / 3952

页数：5

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