Selenium metabolism and regulation of immune cells in immune-associated diseases

被引:14
作者
Niu, Ruiying [1 ]
Yang, Qiuli [1 ]
Dong, Yingjie [1 ]
Hou, Yueru [1 ]
Liu, Guangwei [1 ]
机构
[1] Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, 19 Xinjiekouwai St, Beijing 100875, Peoples R China
关键词
cancer; immune-associated diseases; infection; immune cells; inflammation; selenium metabolism; NITRIC-OXIDE SYNTHASE; T-CELL; SELENOPROTEIN-P; NATURAL-KILLER; TRANSFER-RNA; ALTERNATIVE ACTIVATION; GLUTATHIONE-PEROXIDASE; OXIDATIVE STRESS; DIETARY SELENIUM; SODIUM SELENITE;
D O I
10.1002/jcp.30824
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Selenium, as one of the essential microelements, plays an irreplaceable role in metabolism regulation and cell survival. Selenium metabolism and regulation have great effects on physiological systems especially the immune system. Therefore, selenium is tightly related to various diseases like cancer. Although recent research works have revealed much about selenium metabolism, the ways in which selenium regulates immune cells' functions and immune-associated diseases still remain much unclear. In this review, we will briefly introduce the regulatory role of selenium metabolism in immune cells and immune-associated diseases.
引用
收藏
页码:3449 / 3464
页数:16
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