Molecular Cell Biology and Immunobiology of Mammalian Rod/Ring Structures

被引：43

作者：

Carcamo, Wendy C. ^{[1
]}

Calise, S. John ^{[1
]}

von Muehlen, Carlos A. ^{[2
]}

Satoh, Minoru ^{[3
,4
]}

Chan, Edward K. L. ^{[1
]}

机构：

[1] Univ Florida, Dept Oral Biol, Gainesville, FL 32610 USA

[2] Rheuma Clin Rheumat Dis, Porto Alegre, RS, Brazil

[3] Univ Florida, Dept Med, Div Rheumatol & Clin Immunol, Gainesville, FL USA

[4] Univ Occupat & Environm Hlth, Sch Hlth Sci, Dept Clin Nursing, Kitakyushu, Fukuoka 807, Japan

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 308 | 2014年 / 308卷

关键词：

HEPATITIS-C VIRUS; INOSINE MONOPHOSPHATE DEHYDROGENASE; DOMINANT RETINITIS-PIGMENTOSA; ORGAN-SPECIFIC AUTOANTIBODIES; ACETYL-COA CARBOXYLASE; CHRONIC LIVER-DISEASE; ANTINUCLEAR ANTIBODIES; PEGYLATED INTERFERON; PROCESSING PATHWAYS; MYCOPHENOLIC-ACID;

D O I：

10.1016/B978-0-12-800097-7.00002-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleotide biosynthesis is a highly regulated process necessary for cell growth and replication. Cytoplasmic structures in mammalian cells, provisionally described as rods and rings (RR), were identified by human autoantibodies and recently shown to include two key enzymes of the CTP/GTP biosynthetic pathways, cytidine triphosphate synthetase (CTPS) and inosine monophosphate dehydrogenase (IMPDH). Several studies have described CTPS filaments in mammalian cells, Drosophila, yeast, and bacteria. Other studies have identified IMPDH filaments in mammalian cells. Similarities among these studies point to a common evolutionarily conserved cytoplasmic structure composed of a subset of nucleotide biosynthetic enzymes. These structures appear to be a conserved metabolic response to decreased intracellular GTP and/or CTP pools. Antibodies to RR were found to develop in some hepatitis C patients treated with interferon-alpha and ribavirin. Additionally, the presence of anti-RR antibodies was correlated with poor treatment outcome.

引用

页码：35 / 74

页数：40

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