Social inappropriateness in neurodegenerative disorders

被引:73
作者
Desmarais, Philippe [1 ,2 ,3 ,4 ]
Lanctot, Krista L. [1 ,4 ,5 ]
Masellis, Mario [2 ,3 ,4 ,6 ,7 ]
Black, Sandra E. [4 ,6 ,7 ]
Herrmann, Nathan [4 ,5 ,8 ]
机构
[1] Sunnybrook Hlth Sci Ctr, Geriatr Psychiat, Toronto, ON, Canada
[2] Sunnybrook Hlth Sci Ctr, Cognit & Movement Disorders Clin, 2075 Bayview Ave,Room A4-55, Toronto, ON M4N 3M5, Canada
[3] Sunnybrook Hlth Sci Ctr, LC Campbell Cognit Neurol Res Unit, Toronto, ON, Canada
[4] Sunnybrook Res Inst, Hurvitz Brain Sci Program, Toronto, ON, Canada
[5] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[6] Univ Toronto, Div Neurol, Dept Med, Toronto, ON, Canada
[7] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[8] Sunnybrook Hlth Sci Ctr, Dept Psychiat, Lewar Chair Geriatr Psychiat, Toronto, ON, Canada
基金
美国国家卫生研究院;
关键词
cognitive disorders; mild behavior impairment (MBI); Alzheimer's disease (AD); mild cognitive impairment (MCI); frontotemporal dementia (FTD); MILD COGNITIVE IMPAIRMENT; VARIANT FRONTOTEMPORAL DEMENTIA; NEUROPSYCHIATRIC SYMPTOMS; BEHAVIORAL-VARIANT; ALZHEIMERS-DISEASE; DIAGNOSTIC-CRITERIA; SEROTONERGIC FUNCTION; EMOTION RECOGNITION; FRONTAL VARIANT; FACIAL EMOTION;
D O I
10.1017/S1041610217001260
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background:New onset of mood and behavioral changes in middle-aged patients are frequently the first manifestations of an unrecognized neurocognitive disorder. Impairment of social cognition, the cognitive ability to process social information coming from others, such as emotions, to attribute mental states to others, and to respond appropriately to them, is often at the origin of behavioral manifestations in neurodegenerative disorders.Methods:This paper reviews the current literature on social cognition impairment in neurocognitive disorders, particularly in prodromal stages of behavioral-variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), idiopathic Parkinson's disease (IPD), and Lewy body dementia (LBD). The concepts of social cognition will be reviewed, including its impairment and neural basis, its clinical assessment, and the different therapeutic interventions available clinically.Results:Socially inappropriate behaviors, such as loss of empathy, inappropriateness of affect, and disinhibition are frequently reported in prodromal bvFTD and in prodromal AD. Lack of self-control, reduced perception of social cues, such as recognition of facial emotions and sarcastic speech, and impaired Theory of Mind all contribute to the neuropsychiatric symptoms and are secondary to neurodegeneration in specific brain regions. In contrasts to bvFTD and AD, deficits in social cognition in IPD occur later in the course of the disease and are often multifactorial in origin.Conclusions:Through various manifestations, social inappropriateness is frequently the first clinical sign of a neurodegenerative process, especially in AD and bvFTD, years before noticeable impairment on classical neuropsychological assessment and brain atrophy on imaging.
引用
收藏
页码:197 / 207
页数:11
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