Toward a wholly nutritional therapy for type 2 diabetes

被引：18
作者：
McCarty, MF [1 ]
机构：
[1] Helicon Fdn, San Diego, CA USA
来源：
MEDICAL HYPOTHESES | 2000年 / 54卷 / 03期
关键词：
D O I：
10.1054/mehy.1999.0881
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
It may now be feasible to target specific supplemental nutrients to each of the key dysfunctions which conspire to maintain hyperglycemia in type 2 diabetes: bioactive chromium for skeletal muscle insulin resistance, conjugated linoleic acid for adipocyte insulin resistance, high-dose biotin for excessive hepatic glucose output, and coenzyme Q(10) for beta cell failure. Nutritional strategies which disinhibit hepatic fatty acid oxidation (involving hydroxycitrate, carnitine, pyruvate, and other adjuvants) may likewise prove beneficial - in the short term, by decreasing serum free fatty acids and, in the longer term, by promoting regression of visceral obesity. The nutrients and food factors recommended here appear to be safe and well tolerated, and thus may have particular utility for diabetes prevention. (C) 2000 Harcourt Publishers Ltd.
引用
收藏
页码：483 / 487
页数：5
相关论文
共 84 条
  • [1] IMPROVED ASSAY FOR BIOLOGICALLY-ACTIVE CHROMIUM
    ANDERSON, RA
    BRANTNER, JH
    POLANSKY, MM
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1978, 26 (05) : 1219 - 1221
  • [2] Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes
    Anderson, RA
    Cheng, NZ
    Bryden, NA
    Polansky, MM
    Cheng, NP
    Chi, JM
    Feng, JG
    [J]. DIABETES, 1997, 46 (11) : 1786 - 1791
  • [3] ROLE OF DIET AND EXERCISE IN THE MANAGEMENT OF HYPERINSULINEMIA AND ASSOCIATED ATHEROSCLEROTIC RISK-FACTORS
    BARNARD, RJ
    UGIANSKIS, EJ
    MARTIN, DA
    INKELES, SB
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1992, 69 (05) : 440 - 444
  • [4] LONG-TERM USE OF A HIGH-COMPLEX-CARBOHYDRATE, HIGH-FIBER, LOW-FAT DIET AND EXERCISE IN THE TREATMENT OF NIDDM PATIENTS
    BARNARD, RJ
    MASSEY, MR
    CHERNY, S
    OBRIEN, LT
    PRITIKIN, N
    [J]. DIABETES CARE, 1983, 6 (03) : 268 - 273
  • [5] Dietary conjugated linoleic acid induces peroxisome-specific enzyme accumulation and ornithine decarboxylase activity in mouse liver
    Belury, MA
    MoyaCamarena, SY
    Liu, KL
    Heuvel, JPV
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1997, 8 (10) : 579 - 584
  • [6] THE CALORIGENIC NATURE OF HEPATIC KETOGENESIS - AN EXPLANATION FOR THE STIMULATION OF RESPIRATION INDUCED BY FATTY-ACID SUBSTRATES
    BERRY, MN
    CLARK, DG
    GRIVELL, AR
    WALLACE, PG
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 131 (01): : 205 - 214
  • [7] THE CONTRIBUTION OF HEPATIC-METABOLISM TO DIET-INDUCED THERMOGENESIS
    BERRY, MN
    CLARK, DG
    GRIVELL, AR
    WALLACE, PG
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1985, 34 (02): : 141 - 147
  • [8] PORTAL ADIPOSE-TISSUE AS A GENERATOR OF RISK-FACTORS FOR CARDIOVASCULAR-DISEASE AND DIABETES
    BJORNTORP, P
    [J]. ARTERIOSCLEROSIS, 1990, 10 (04): : 493 - 496
  • [9] BODEN G, 1996, DIABETES, V45, P3
  • [10] COMPARISON OF THE EFFECTS ON INSULIN SENSITIVITY OF HIGH-CARBOHYDRATE AND HIGH-FAT DIETS IN NORMAL SUBJECTS
    BORKMAN, M
    CAMPBELL, LV
    CHISHOLM, DJ
    STORLIEN, LH
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (02) : 432 - 437
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