MODELING FUNCTIONAL DECLINE OVER TIME IN SPORADIC INCLUSION BODY MYOSITIS

被引：15

作者：

Alfano, Lindsay N. ^{[1
]}

Yin, Han ^{[2
]}

Dvorchik, Igor ^{[2
]}

Maus, Elizabeth G. ^{[1
]}

Flanigan, Kevin M. ^{[1
]}

Mendell, Jerry R. ^{[1
]}

Lowes, Linda P. ^{[1
]}

机构：

[1] Nationwide Childrens Hosp, Ctr Gene Therapy, Res Inst, 700 Childrens Dr,Room AB1042, Columbus, OH 43205 USA

[2] Nationwide Childrens Hosp Biostat Core, Res Inst, Columbus, OH USA

来源：

MUSCLE & NERVE | 2017年 / 55卷 / 04期

关键词：

disease progression; function; natural history; logistic model; sporadic inclusion body myositis; DISEASE PROGRESSION; STRENGTH; THERAPY;

D O I：

10.1002/mus.25373

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The ability to individualize recommendations or expectations of disease progression based on a patient's unique characteristics has merit for use in sporadic inclusion body myositis (sIBM). Methods: Fifty-five subjects with sIBM completed a battery of strength and functional outcomes at 2 study visits. These were used to develop mathematical models of disease progression in patients with sIBM for use in clinical and research settings. Results: The 6-minute walk test (6MWT) distance declined by an average of 27.5 meters (12%) per year. Significant factors that predict 6MWT were knee extension and plantarflexion strength and body weight, whereas the ability to stand from a chair was impacted by elbow extension strength. Stepping up on a curb was influenced by the patient's age at diagnosis and by knee extension. Statistical models to predict functional decline in sIBM were developed. Conclusion: Statistical models help explain the complex factors that influence decreased walking ability and other functional activities in sIBM.

引用

页码：526 / 531

页数：6

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