Synthesis and biological evaluation of 1,2-dihydro-2,11B-diazabenzo[de]anthracen-one derivatives as potent poly(ADP-ribose) polymerase (PARP-1) inhibitors.

被引：0
|
作者：
Xu, WZ [1 ]
Chen, J [1 ]
Grella, B [1 ]
Ko, YS [1 ]
Huang, S [1 ]
Lauter, S [1 ]
Li, JH [1 ]
Liu, Q [1 ]
Williams, L [1 ]
Wu, QY [1 ]
Zhang, J [1 ]
Kalish, V [1 ]
机构：
[1] Guilford Pharmaceut Inc, Baltimore, MD 21224 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 227卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
016-MEDI
引用
收藏
页码：U7 / U7
页数：1
相关论文
共 50 条
  • [31] Studies on Benzofuran-7-carboxamides as Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors
    Lee, Sunkyung
    Yi, Kyu Yang
    Lee, Byung Ho
    Oh, Kwang Seok
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 33 (04) : 1147 - 1153
  • [32] Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)
    Pescatore, Giovanna
    Branca, Danila
    Fiore, Fabrizio
    Kinzel, Olaf
    Bufi, Laura Llauger
    Muraglia, Ester
    Orvieto, Federica
    Rowley, Michael
    Toniatti, Carlo
    Torrisi, Caterina
    Jones, Philip
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (03) : 1094 - 1099
  • [33] Synthesis, [18F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography
    Zhou, Dong
    Chu, Wenhua
    Xu, Jinbin
    Jones, Lynne A.
    Peng, Xin
    Li, Shihong
    Chen, Delphine L.
    Mach, Robert H.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (05) : 1700 - 1707
  • [34] Synthesis and evaluation of thiopyrano[3,4-c]quinoline-9-carboxamide derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)
    Chun-Ho Park
    Kwangwoo Chun
    Bo-Young Joe
    Jong-Hee Choi
    Han-Chang Lee
    Il-Whea Ku
    Hyun Young Kim
    Seong-Ho Koh
    Goang Won Cho
    Seung Hyun Kim
    Myung-Hwa Kim
    Medicinal Chemistry Research, 2012, 21 : 1533 - 1543
  • [35] Synthesis and evaluation of thiopyrano[3,4-c]quinoline-9-carboxamide derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)
    Park, Chun-Ho
    Chun, Kwangwoo
    Joe, Bo-Young
    Choi, Jong-Hee
    Lee, Han-Chang
    Ku, Il-Whea
    Kim, Hyun Young
    Koh, Seong-Ho
    Cho, Goang Won
    Kim, Seung Hyun
    Kim, Myung-Hwa
    MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (08) : 1533 - 1543
  • [36] Discovery of Novel Bromophenol Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer
    Guo, Chuanlong
    Wang, Lijun
    Li, Xinxue
    Wang, Shuaiyu
    Yu, Xuemin
    Xu, Kuo
    Zhao, Yue
    Luo, Jiao
    Li, Xiangqian
    Jiang, Bo
    Shi, Dayong
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (06) : 3051 - 3067
  • [37] Inhibition of cell necrosis by novel adenosine substituted poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors
    Jagtap, P
    Southan, GJ
    Baloglu, E
    Ram, S
    Mabley, JG
    Marton, A
    Salzman, AL
    Szabo, C
    FASEB JOURNAL, 2004, 18 (05): : A1193 - A1193
  • [38] Design, synthesis, and biological evaluation of 2H-7-oxa-1,2-diaza-benzo[de]anthracen-3-one derivatives as potent PARP-1 inhibitors
    Xu, Weizheng
    Wilcoxen, Keith
    Zhang, Jie
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [39] Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer
    Long, Huan
    Hu, Xiaolong
    Wang, Baolin
    Wang, Quan
    Wang, Rong
    Liu, Shumeng
    Xiong, Fei
    Jiang, Zhenzhou
    Zhang, Xiao-Qi
    Ye, Wen-Cai
    Wang, Hao
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (16) : 12089 - 12108
  • [40] Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly (ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents
    Tong, Yunsong
    Bouska, Jennifer J.
    Ellis, Paul A.
    Johnson, Eric F.
    Leverson, Joel
    Liu, Xuesong
    Marcotte, Patrick A.
    Olson, Amanda M.
    Osterling, Donald J.
    Przytulinska, Magdalena
    Rodriguez, Luis E.
    Shi, Yan
    Soni, Nirupama
    Stavropoulos, Jason
    Thomas, Sheela
    Donawho, Cherrie K.
    Frost, David J.
    Luo, Yan
    Giranda, Vincent L.
    Penning, Thomas D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (21) : 6803 - 6813
12345