Immune-Mediated Therapies for Liver Cancer

被引：23
作者：
Aravalli, Rajagopal N. [1 ]
Steer, Clifford J. [2 ]
机构：
[1] Univ Minnesota, Dept Elect & Comp Engn, 200 Union St SE, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Med & Genet Cell Biol & Dev, 420 Delaware St SE, Minneapolis, MN 55455 USA
来源：
GENES | 2017年 / 8卷 / 02期
关键词：
adaptive immunity; adoptive cell transfer; cancer vaccines; cholangiocarcinoma; hepatocellular carcinoma; immune checkpoint blockade; immunotherapy; innate immunity; tumor immunology; INDUCED KILLER-CELLS; HUMAN CHOLANGIOCARCINOMA CELLS; TUMOR-ASSOCIATED MACROPHAGES; ANTIGEN-PRESENTING CELLS; HEPATOCELLULAR-CARCINOMA; T-CELL; ANTIPLATELET THERAPY; KUPFFER CELLS; ADOPTIVE IMMUNOTHERAPY; RECURRENCE RATES;
D O I：
10.3390/genes8020076
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In recent years, immunotherapy has gained renewed interest as an alternative therapeutic approach for solid tumors. Its premise is based on harnessing the power of the host immune system to destroy tumor cells. Development of immune-mediated therapies, such as vaccines, adoptive transfer of autologous immune cells, and stimulation of host immunity by targeting tumor-evasive mechanisms have advanced cancer immunotherapy. In addition, studies on innate immunity and mechanisms of immune evasion have enhanced our understanding on the immunology of liver cancer. Preclinical and clinical studies with immune-mediated therapies have shown potential benefits in patients with liver cancer. In this review, we summarize current knowledge and recent developments in tumor immunology by focusing on two main primary liver cancers: hepatocellular carcinoma and cholangiocarcinoma.
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页数：20
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