Angiogenesis and non-small cell lung cancer

被引：95

作者：

Cox, G

Jones, JL

Walker, RA

Steward, WP

O'Byrne, KJ

机构：

[1] Leicester Royal Infirm, Univ Dept Med Oncol, Leicester LE1 5WW, Leics, England

[2] Glenfield Gen Hosp, Dept Resp Med, Leicester LE3 9QP, Leics, England

[3] Glenfield Gen Hosp, Dept Pathol, Leicester LE3 9QP, Leics, England

来源：

LUNG CANCER | 2000年 / 27卷 / 02期

关键词：

angiogenesis; matrix metalloproteinases; growth factors; apoptosis; non-small cell lung cancer;

D O I：

10.1016/S0169-5002(99)00096-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is the commonest cause of cancer death in the western world. Recent evidence suggests that angiogenesis is related to poor prognosis in many solid tumours including non-small cell lung cancer. Angiogenesis is controlled by a complex interaction between growth and apoptotic factors, proteases and adhesion molecules. The angiogenic process may prove a target for novel therapies such as matrix metalloproteinase inhibitors, growth factor antisense RNA, growth factor. receptor antagonists and naturally occurring antiangiogenic peptides. These agents may be used alone ol in combination with traditional chemotherapy, radiotherapy and surgery. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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页码：81 / 100

页数：20

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