In the vegetation periods of 2016-2017 and 2017-2018 a field trial with winter wheat (Triticum aestivum L.) was conducted. The experiment was situated on the field of the Base for Training and Implementation of the Agricultural University of Plovdiv, Bulgaria. Five herbicide products with mixed mode of action were evaluated and were compared with untreated control. The study was designed to examine the efficacy and selectivity of the following herbicide products: Pallas (R) 75 WG (75 g/kg pyroxsulam), Corello (R) Duo WG (70.8 g/kg pyroxsulam + 14.2 g/kg florasulam + 70.8 g/kg cloquintocet-mexil), Atlantis (R) Flex WG (45 g/kg mezosulfuron-methyl + 67.5 g/kg propoxycarbazonsodium + mefenpir-diethil), Axial (R) One EC (45 g/l pinoxaden + 5 g/l florasulam) and Celio (R) WG (200 g/kg clodinafop-propargyl + 75 g/kg pyroxulam + 75 g/kg cloquintocet-mexil). All treatments were replicated 4 times. The existing weed species on the field were Anthemis arvensis L., Papaver rhoeas L., Galium aparine L., Descurainia sophia L., Sinapis arvensis L., Lolium multiflorum Lam., Avena fatua L. as well as the volunteers Coriandrum sativum L. and Clearfield (R) Brassica napus L. The highest efficacy was recorded against S. arvensis after all herbicide applications. The lowest efficacy was found to be against the volunteer B. napus. Average for both experimental years the highest winter wheat grain yield was reported after the treatment with Atlantis (R) Flex WG -4.38 t/ha.