COMPUTATIONAL MODELS FOR FLUID EXCHANGE BETWEEN MICROCIRCULATION AND TISSUE INTERSTITIUM

被引:38
作者
Cattaneo, Laura [1 ]
Zunino, Paolo [2 ]
机构
[1] Politecn Milan, MOX, Dept Math Francesco Brioschi, I-20133 Milan, Italy
[2] Univ Pittsburgh, Dept Mech Engn & Mat Sci, Pittsburgh, PA 15261 USA
关键词
Perfusion; intestitial flow; tumors enhanced permeability and retention; immersed boundary method; BLOOD-FLOW; TRANSPORT; TUMORS; MACROMOLECULES; EQUATIONS; ANGIOGENESIS; NETWORKS; PRESSURE; VESSEL; CANCER;
D O I
10.3934/nhm.2014.9.135
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
The aim of this work is to develop a computational model able to capture the interplay between microcirculation and interstitial flow. Such phenomena are at the basis of the exchange of nutrients, wastes and pharmacological agents between the cardiovascular system and the organs. They are particularly interesting for the study of effective therapies to treat vascularized tumors with drugs. We develop a model applicable at the microscopic scale, where the capillaries and the interstitial volume can be described as independent structures capable to propagate flow. We facilitate the analysis of complex capillary bed configurations, by representing the capillaries as a one-dimensional network, ending up with a heterogeneous system characterized by channels embedded into a porous medium. We use the immersed boundary method to couple the one-dimensional with the three-dimensional flow through the network and the interstitial volume, respectively. The main idea consists in replacing the immersed network with an equivalent concentrated source term. After discussing the details for the implementation of a computational solver, we apply it to compare flow within healthy and tumor tissue samples.
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页码:135 / 159
页数:25
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