The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep

被引：95
作者：
Strain, SAJ
Bishop, SC
Henderson, NG
Kerr, A
McKellar, QA
Mitchell, S
Stear, MJ
机构：
[1] Univ Glasgow, Dept Vet Clin Studies, Sch Vet, Glasgow G61 1QH, Lanark, Scotland
[2] Moredun Res Inst, Penicuik EH26 0PZ, Midlothian, Scotland
[3] Roslin Inst Edinburgh, Roslin EH25 9PS, Midlothian, Scotland
来源：
PARASITOLOGY | 2002年 / 124卷
关键词：
sheep; nematoda; Teladorsagia circumcincta; IgA; marker; indicator trait;
D O I：
10.1017/S0031182002001531
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Previous studies in deliberately infected sheep have shown an association between IgA activity against 4th-stage larvae of Teladorsagia circumcincta and parasite growth, development and fecundity. The purpose of this research,,vas to determine if these results could be confirmed in naturally infected sheep and to explore the hypothesis that plasma IgA activity could help to identify resistant lambs with shorter adult nematodes. Plasma IgA activity was skewed with most animals having relatively low levels of IgA activity. Plasma IgA activity, was repeatable and highly heritable. Animals with increased IgA activity had lower egg counts and shorter adult female T. circumcincta. Therefore, under conditions of natural parasite challenge, plasma IgA activity, may help to identify lambs resistant to T. circumcincta.
引用
收藏
页码：545 / 552
页数：8
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