Enterococcal isolates carrying the novel oxazolidinone resistance gene optrA from hospitals in Zhejiang, Guangdong, and Henan, China, 2010-2014

被引：80

作者：

Cai, J. ^{[1
]}

Wang, Y. ^{[2
]}

Schwarz, S. ^{[3
]}

Lv, H. ^{[4
]}

Li, Y. ^{[5
]}

Liao, K. ^{[6
]}

Yu, S. ^{[7
]}

Zhao, K. ^{[8
]}

Gu, D. ^{[1
]}

Wang, X. ^{[1
]}

Zhang, R. ^{[1
]}

Shen, J. ^{[2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Clin Microbiol Lab, Hangzhou 310003, Zhejiang, Peoples R China

[2] China Agr Univ, Coll Vet Med, Dept Vet Pharmacol, Beijing 100193, Peoples R China

[3] FLI, Inst Farm Anim Genet, Neustadt, Germany

[4] Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China

[5] Henan Prov Peoples Hosp, Zhengzhou, Peoples R China

[6] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China

[7] Taizhou Hosp, Taizhou, Peoples R China

[8] Peoples Hosp Cixi, Cixi, Peoples R China

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2015年 / 21卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Antimicrobial resistance; enterococci; linezolid; molecular epidemiology; nosocomial infection; phenicols; tedizolid; SEQUENCE TYPING SCHEME; FAECALIS; FAECIUM; ANTIBIOTICS; INFECTIONS; PHENICOLS; CFR;

D O I：

10.1016/j.cmi.2015.08.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A collection of 1159 enterococcal isolates from five Chinese hospitals were screened for the presence of the novel oxazolidinone resistance gene optrA, which was found in 34 (2.9%) isolates. Pulsed-field gel electrophoresis (PFGE) typing of 29 optrA-carrying Enterococcus faecalis isolates revealed 25 PFGE patterns, and multilocus sequence typing yielded 20 sequence types. Routine surveillance of optrA-positive enterococci in hospitals should be conducted to monitor and counteract their further dissemination. The data of this study may be used as a baseline from which to judge future decreases or increases in optrA-positive enterococci. Clinical Microbiology and Infection (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：1095.e1 / 1095.e4

页数：4

共 15 条

[1]

[Anonymous], 2015, PERF STAND ANT SUSC

[2] Comparative In Vitro Antimicrobial Activities of Torezolid (TR-700), the Active Moiety of a New Oxazolidinone, Torezolid Phosphate (TR-701), Determination of Tentative Disk Diffusion Interpretive Criteria, and Quality Control Ranges [J].

Brown, Steven D. ;

Traczewski, Maria M. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) :2063-2069

[3]

Clinical Laboratory Standards Institute, 2015, METH DIL ANT SUSC TE, V9th

[4] Multilocus sequence typing scheme for Enterococcus faecium [J].

Homan, WL ;

Tribe, D ;

Poznanski, S ;

Li, M ;

Hogg, G ;

Spalburg, E ;

van Embden, JDA ;

Willems, RJL .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (06) :1963-1971

[5] FDA Guidance for ABSSSI Trials: Implications for Conducting and Interpreting Clinical Trials [J].

Itani, Kamal M. F. ;

Shorr, Andrew F. .

CLINICAL INFECTIOUS DISEASES, 2014, 58 :S4-S9

[6] Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit [J].

Johnson, AP ;

Tysall, L ;

Stockdale, MW ;

Woodford, N ;

Kaufmann, ME ;

Warner, M ;

Livermore, DM ;

Asboth, F ;

Allerberger, FJ .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2002, 21 (10) :751-754

[7] Tedizolid for the Management of Human Infections: In Vitro Characteristics [J].

Locke, Jeffrey B. ;

Zurenko, Gary E. ;

Shaw, Karen Joy ;

Bartizal, Kenneth .

CLINICAL INFECTIOUS DISEASES, 2014, 58 :S35-S42

[8] The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptograrnin A antibiotics [J].

Long, Katherine S. ;

Poehlsgaard, Jacob ;

Kehrenberg, Corinna ;

Schwarz, Stefan ;

Vester, Birte .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (07) :2500-2505

[9] Linezolid update: Stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms [J].

Mendes, Rodrigo E. ;

Deshpande, Lalitagauri M. ;

Jones, Ronald N. .

DRUG RESISTANCE UPDATES, 2014, 17 (1-2) :1-12

[10] Tedizolid: A Novel Oxazolidinone for Gram-Positive Infections [J].

Moellering, Robert C., Jr. .

CLINICAL INFECTIOUS DISEASES, 2014, 58 :S1-S3

← 1 2 →