Hepatocyte growth factor scatter factor Met signaling in tumorigenicity and invasion/metastasis

被引：282
|
作者：
Jeffers, M [1 ]
Rong, S [1 ]
VandeWoude, GF [1 ]
机构：
[1] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21702
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 1996年 / 74卷 / 09期
关键词：
hepatocyte growth factor scatter factor; Met; tumorigenicity; invasion; metastasis;
D O I：
10.1007/BF00204976
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Hepatocyte growth factor/scatter factor (HCF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy.
引用
收藏
页码：505 / 513
页数：9
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