Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

被引：51

作者：

Siddiqui, Arif Jamal ^{[1
]}

Danciu, Corina ^{[2
]}

Ashraf, Syed Amir ^{[3
]}

Moin, Afrasim ^{[4
]}

Singh, Ritu ^{[5
]}

Alreshidi, Mousa ^{[1
]}

Patel, Mitesh ^{[6
]}

Jahan, Sadaf ^{[7
]}

Kumar, Sanjeev ^{[8
]}

Alkhinjar, Mulfi I. M. ^{[9
]}

Badraoui, Riadh ^{[1
,10
,11
]}

Snoussi, Mejdi ^{[1
,12
]}

Adnan, Mohd ^{[1
]}

机构：

[1] Univ Hail, Coll Sci, Dept Biol, POB 2440, Hail, Saudi Arabia

[2] Victor Babes Univ Med & Pharm, Dept Pharmacognosy, Fac Pharm, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[3] Univ Hail, Coll Appl Med Sci, Dept Clin Nutr, POB 2440, Hail, Saudi Arabia

[4] Univ Hail, Coll Pharm, Dept Pharmaceut, POB 2440, Hail, Saudi Arabia

[5] Cent Univ Rajasthan, Sch Earth Sci, Dept Environm Sci, Ajmer 305817, Rajasthan, India

[6] Veer Narmad South Gujarat Univ, Bapalal Vaidya Bot Res Ctr, Dept Biosci, Surat 395007, Gujarat, India

[7] Majmaah Univ, Coll Appl Med Sci, Dept Med Lab, Al Majmaah 15341, Saudi Arabia

[8] Cent Univ Jharkhand, Dept Environm Sci, Ranchi 835205, India

[9] Saudi Ctr Dis Prevent & Control, King Abdulaziz Rd, Riyadh 13354, Saudi Arabia

[10] Univ Tunis El Manar, Sect Histol Cytol, Med Coll Tunis, La Rabta Tunis 1007, Tunisia

[11] Univ Sfax, Med Coll Sfax, Lab Histoembryol & Cytogenet, Sfax 3029, Tunisia

[12] Univ Monastir, Higher Inst Biotechnol Monastir, Lab Genet Biodivers & Valorizat Bioresources, Monastir 5000, Tunisia

来源：

PLANTS-BASEL | 2020年 / 9卷 / 09期

关键词：

SARS-CoV; COVID-19; coronavirus; medicinal plant; phytomedicine; ethnobotany; antiviral; natural products; bioactive compounds; PAPAIN-LIKE PROTEASE; CITRUS-AURANTIUM L; MESSENGER-RNA EXPRESSION; SAMBUCUS-NIGRA L; ALLIUM-SATIVUM L; CIMICIFUGA-FOETIDA; TARAXACUM-OFFICINALE; IN-VITRO; GERANYLATED FLAVONOIDS; SALVIA-MILTIORRHIZA;

D O I：

10.3390/plants9091244

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroying the world economy and social life, with increased mortality rate each day. To date, there is no specific medicine or vaccine available against this pandemic disease. However, the presence of medicinal plants and their bioactive molecules with antiviral properties might also be a successful strategy in order to develop therapeutic agents against SARS-CoV-2 infection. Thus, this review will summarize the available literature and other information/data sources related to antiviral medicinal plants, with possible ethnobotanical evidence in correlation with coronaviruses. The identification of novel antiviral compounds is of critical significance, and medicinal plant based natural compounds are a good source for such discoveries. In depth search and analysis revealed several medicinal plants with excellent efficacy against SARS-CoV-1 and MERS-CoV, which are well-known to act on ACE-2 receptor, 3CLpro and other viral protein targets. In this review, we have consolidated the data of several medicinal plants and their natural bioactive metabolites, which have promising antiviral activities against coronaviruses with detailed modes of action/mechanism. It is concluded that this review will be useful for researchers worldwide and highly recommended for the development of naturally safe and effective therapeutic drugs/agents against SARS-CoV-2 infection, which might be used in therapeutic protocols alone or in combination with chemically synthetized drugs.

引用

页码：1 / 41

页数：41

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