Important differences between topoisomerase-I and -II targeting agents

被引：11

作者：

Banerji, Shantanu ^{[1
]}

Los, Marek ^{[1
]}

机构：

[1] Manitoba Inst Cell Biol, Canada Res Chair Canc Therapy Dev, Winnipeg, MB R3E 0V9, Canada

来源：

关键词：

mitoxantrone; topotecan; topoisomerase targeting agents; reactive oxygen species (ROS); X2HS;

D O I：

10.4161/cbt.5.8.3274

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：965 / 966

页数：2

共 20 条

[1] Guiding ATM to broken DNA
Abraham, RT
Tibbetts, RS
[J]. SCIENCE, 2005, 308 (5721) : 510 - 511
[2] Banáth JP, 2003, CANCER RES, V63, P4347
[3] Burma S, 2001, J BIOL CHEM, V276, P42462, DOI 10.1074/jbc.C100466200
[4] DOROSHOW JH, 2006, CANC CHEMOTHERAPY BI
[5] HSIANG YH, 1988, CANCER RES, V48, P1722
[6] HSIANG YH, 1989, CANCER RES, V49, P5077
[7] HSIANG YH, 1985, J BIOL CHEM, V260, P4873
[8] Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine
Huang, Xuan
Kurose, Akira
Tanaka, Toshiki
Traganos, Frank
Dai, Wei
Darzynkiewicz, Zbigniew
[J]. CANCER BIOLOGY & THERAPY, 2006, 5 (08) : 959 - 964
[9] Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species
Kurz, EU
Douglas, P
Lees-Miller, SP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (51) : 53272 - 53281
[10] Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase
Lu, HR
Zhu, H
Huang, M
Chen, Y
Cai, YJ
Miao, ZH
Zhang, JS
Ding, J
[J]. MOLECULAR PHARMACOLOGY, 2005, 68 (04) : 983 - 994