Co-assembled Supramolecular Gel of Dipeptide and Pyridine Derivatives with Controlled Chirality

It is commonly considered that amyloid-beta (A beta) fibrils are heavily involved in the neurological diseases. Establishing an external model based on the core recognition motif (diphenylalanine, FF) of A beta would be of significance in understanding the assembly and disassembly of A beta fibrils in living system. Herein, supramolecular gels with structure transition from amyloid-like beta-sheet to different supramolecular helices were obtained through the co-assembly of a N-fluorenylmethoxycarbonyl-protected L-FF (L-FmocFF) with achiral pyridine derivatives. It is found that the different stacking modes (H- or J-aggregates) of additives and the microenvironment of chiral carbon play vital roles for the selectively chiral transfer or amplification of L-FmocFF. The dynamic process of helix formation was also captured. This work provides a convenient co-assembly way to explore the structure basis of A beta fibrils with a controlled chirality.