Maternal Measles Antibodies and Their Influence on All-cause Mortality Following Measles Vaccination: An Alternative to Measure Very Low Maternal Antibody Levels

被引：2

作者：

Smits, Gaby ^{[1
]}

Benn, Christine Stabell ^{[2
,3
]}

Whittle, Hilton ^{[4
]}

van Binnendijk, Rob ^{[1
]}

Aaby, Peter ^{[5
]}

van der Klis, Fiona ^{[1
]}

机构：

[1] Natl Inst Puhl Hlth & Environm, Ctr Immunol Infect Dis & Vaccines, Bilthoven, Netherlands

[2] Statens Serum Inst, Bandim Hlth Project, Res Ctr Vitamins & Vaccines, Copenhagen, Denmark

[3] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res & DIPS, OPEN, Odense, Denmark

[4] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England

[5] INDEPTH Netwoik, Projecto Saude Bandim, Bissau, Guinea Bissau

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 10期

基金：

欧洲研究理事会;

关键词：

maternal measles antibodies; all-cause mortality; HAI; multiplex immunoassay; RUBELLA; MUMPS; VARICELLA;

D O I：

10.1093/cid/ciy900

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower allcause mortality (P=.02).

引用

页码：1758 / 1760

页数：3

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