Tyrosine kinase inhibitors are potent and selective inhibitors of UGT1A1: Tools for UGT phenotyping

被引:0
作者
Kalyanaraman, Nataraj
Li, Chun
Surapaneni, Sekhar S.
Kumar, Gondi N.
机构
[1] Amgen Inc, PKDM, Thousand Oaks, CA 91320 USA
[2] Amgen Inc, Dept PKDM MS, Newbury Pk, CA USA
[3] Amgen Inc, Dept PKDM MS, Thousand Oaks, CA 91320 USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
74
引用
收藏
页码:43 / 43
页数:1
相关论文
共 50 条
  • [21] Potent and selective inhibitors of the FGF receptor-1 tyrosine kinase
    Westwell, AD
    DRUG DISCOVERY TODAY, 2001, 6 (07) : 379 - 379
  • [22] The Development of UGT1A1 and UGT1A6 in Pediatric Liver
    Miyagi, Shogo J.
    Abby, C.
    DRUG METABOLISM REVIEWS, 2009, 41 : 17 - 18
  • [23] Performance of In Silico Tools for the Evaluation of UGT1A1 Missense Variants
    Rodrigues, Carina
    Santos-Silva, Alice
    Costa, Elisio
    Bronze-da-Rocha, Elsa
    HUMAN MUTATION, 2015, 36 (12) : 1215 - 1225
  • [24] The use of chemical inhibitors in the UGT reaction phenotyping of acetaminophen
    Bauman, Jonathan Neal
    Mutlib, Abdul E.
    Goosen, Theunis C.
    DRUG METABOLISM REVIEWS, 2006, 38 : 46 - 46
  • [25] Inhibition of UGT1A1*1 and UGT1A1*6 catalyzed glucuronidation of SN-38 by silybins
    Li, Wei
    Chen, Yin-Nan
    Chen, Yue-Yue
    Wang, Zhe
    Wang, Zhen
    Jiang, Li-Li
    Shi, Hong-Can
    Liu, Yong
    CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 368
  • [26] The small-molecule tyrosine kinase inhibitor nilotinib is a potent noncompetitive inhibitor of the SN-38 glucuronidation by human UGT1A1
    Fujita, Ken-ichi
    Sugiyama, Minako
    Akiyama, Yuko
    Ando, Yuichi
    Sasaki, Yasutsuna
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 67 (01) : 237 - 241
  • [27] Severe irinotecan-induced toxicity in a patient with UGT1A1*28 and UGT1A1*6 polymorphisms
    Xu, Jian-Ming
    Wang, Yan
    Ge, Fei-Jiao
    Lin, Li
    Liu, Ze-Yuan
    Sharma, Manish R.
    WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (24) : 3899 - 3903
  • [28] Correlation of bilirubin glucuronidation and estradiol-3-glucuronidation by UGT1A1: studies with model inhibitors
    Zhou, Jin
    Tracy, Timothy S.
    Remmel, Rory P.
    DRUG METABOLISM REVIEWS, 2009, 41 : 43 - 43
  • [29] The small-molecule tyrosine kinase inhibitor nilotinib is a potent noncompetitive inhibitor of the SN-38 glucuronidation by human UGT1A1
    Ken-ichi Fujita
    Minako Sugiyama
    Yuko Akiyama
    Yuichi Ando
    Yasutsuna Sasaki
    Cancer Chemotherapy and Pharmacology, 2011, 67 : 237 - 241
  • [30] Severe irinotecan-induced toxicity in a patient with UGT1A1*28 and UGT1A1*6 polymorphisms
    Jian-Ming Xu
    Yan Wang
    Fei-Jiao Ge
    Li Lin
    Ze-Yuan Liu
    Manish R Sharma
    World Journal of Gastroenterology, 2013, 19 (24) : 3899 - 3903