Sulfamic acid-catalyzed multicomponent synthesis of 7-phenyl-7,12 dihydrobenzo(h)pyrido[2,3-b]naphthydrin-6(5H)-one derivatives: a green avenue

被引：6

作者：

Jadhav, Sunetra J. ^{[1
]}

Patil, Reshma B. ^{[1
]}

Kumbhar, Digambar R. ^{[1
]}

Patravale, Ajinkya A. ^{[2
,3
]}

Chandam, Dattatraya R. ^{[2
]}

Deshmukh, Madhukar B. ^{[1
,2
]}

机构：

[1] Shivaji Univ, Dept Agrochem & Pest Management, Kolhapur 416004, Maharashtra, India

[2] Shivaji Univ, Dept Chem, Med Chem Res Lab, Kolhapur 416004, MS, India

[3] Vivekanand Coll, Dept Chem, Kolhapur 416004, MS, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2017年 / 43卷 / 04期

关键词：

Atom economy; Multicomponent reactions; Sulfamic acid; 2-Amino pyridine; Naphthydrin derivatives; HIV-1 INTEGRASE INHIBITORS; RECYCLABLE CATALYST; EFFICIENT; NANOPARTICLES; NANOCATALYST; POTENCY; DESIGN; AGENTS;

D O I：

10.1007/s11164-016-2778-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 7-phenyl-7,12-dihydrobenzo(h)pyrido[2,3-b]naphthydrin-6(5H)-one were synthesized by a one-pot three-component condensation of 2,4-dihydroxyquinoline, 2-amino pyridine and various aromatic aldehydes with sulfamic acid as an enviro-economic catalyst. The salient features of this method consist of high atom economy and yields, short reaction time, non-carcinogenic solvents, and chromatography-free work-up procedure. Fascinatingly, the catalyst can be reused for up to four cycles giving good to excellent yields. By employing this method, a series of 14 pyrido[2,3-b]naphthydrin compounds were synthesized. This procedure is projected as a green avenue in the combinatorial synthesis of biologically active naphthydrin derivatives.

引用

页码：2529 / 2543

页数：15

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