Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by Na2S2O4

被引：3
作者：
Yu, Nianhua [1 ]
Huang, Jianjian [1 ]
Leng, Faqiang [1 ]
机构：
[1] Capital Med Univ, Sch Pharmaceut Sci, Beijing 100069, Peoples R China
来源：
RSC ADVANCES | 2022年 / 13卷 / 01期
基金：
北京市自然科学基金;
关键词：
SODIUM TRIFLUOROMETHANESULFINATE; DIRECT TRIFLUOROMETHYLTHIOLATION; METAL; PERFLUOROALKYLTHIOLATION; DIFLUOROMETHYLTHIOLATION;
D O I：
10.1039/d2ra07430c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of Na2S2O4. In this work, we employed readily available iodofluoroethane and Na2S2O4 as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of indole substrates. In addition, fluoroalkylthiolated 2,3 '-biindole derivatives can also be prepared by this method.
引用
收藏
页码：730 / 733
页数：4
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