Influence of Mesenchymal Stem Cell Administration on The Outcome of Partial Liver Resection in a Porcine Model of Sinusoidal Obstruction Syndrome

被引：3

作者：

Palek, Richard ^{[1
,2
]}

Rosendorf, Jachym ^{[1
,2
]}

Maleckova, Anna ^{[2
,3
]}

Vistejnova, Lucie ^{[2
,3
]}

Bajcurova, Kristyna ^{[2
,4
]}

Mirka, Hynek ^{[2
,4
]}

Tegl, Vaclav ^{[2
,5
]}

Brzon, Ondrej ^{[2
]}

Kumar, Arvind ^{[2
]}

Bednar, Lukas ^{[2
]}

Tonar, Zbynek ^{[2
,3
]}

Hosek, Petr ^{[2
]}

Moulisova, Vladimira ^{[2
]}

Eberlova, Lada ^{[2
,6
]}

Treska, Vladislav ^{[1
]}

Liska, Vaclav ^{[1
,2
]}

机构：

[1] Charles Univ Prague, Fac Med Pilsen, Dept Surg, Plzen, Czech Republic

[2] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Plzen, Czech Republic

[3] Charles Univ Prague, Fac Med Pilsen, Dept Histol & Embryol, Plzen, Czech Republic

[4] Charles Univ Prague, Fac Med Pilsen, Dept Med Imaging, Plzen, Czech Republic

[5] Charles Univ Prague, Fac Med Plzen, Dept Anesthesiol & Resuscitat, Plzen, Czech Republic

[6] Charles Univ Prague, Fac Med Pilsen, Dept Anat, Plzen, Czech Republic

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 12期

关键词：

Sinusoidal obstruction syndrome; colorectal cancer; liver metastases; liver resection; mesenchymal stem cells; monocrotaline; HEPATIC VENOOCCLUSIVE DISEASE; PLATELET-AGGREGATION; SURGICAL-TREATMENT; ANIMAL-MODELS; RISK-FACTORS; RAT MODEL; TRANSPLANTATION; REGENERATION; CHEMOTHERAPY; SUPPRESSION;

D O I：

10.21873/anticanres.14704

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In patients with colorectal liver metastases, the possibility for radical liver resection can be limited by oxaliplatin-induced sinusoidal obstruction syndrome (SOS). This study investigates the potential of mesenchymal stem cells (MSC) to improve the outcome of liver resections in pigs with SOS. Materials and Methods: SOS was induced in all animals (n=20) on day 0. Animals in the experimental group (n=8) received allogeneic MSC on day 7. Liver resection was performed in all animals on day 14 and the animals were observed until day 28. Ultrasound volumetry, biochemical analysis and histological examination of liver parenchyma was performed during the follow-up period. Results: Six animals from the control group died prematurely, while all animals survived in the experimental group. According to histology, biochemical analysis and ultrasound volumetry, there were no significant differences between the groups documenting the effect of MSC. Conclusion: Single dose allogeneic MSC administration improved survival of animals with SOS undergoing partial liver resection. Further experiments with different timing of liver resection and MSC administration should be performed to investigate the effect of MSC in more detail.

引用

页码：6817 / 6833

页数：17

共 60 条

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