Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility

被引：12
|
作者：
Carmen Puertas, Maria [1 ]
Jose Buzon, Maria [1 ]
Artese, Anna [2 ]
Alcaro, Stefano [2 ]
Menendez-Arias, Luis [3 ,4 ]
Perno, Carlo Federico [5 ]
Clotet, Bonaventura [1 ]
Ceccherini-Silberstein, Francesca [5 ]
Martinez-Picado, Javier [1 ,6 ]
机构：
[1] IrsiCaixa Fdn, Hosp Germans Trias & Pujol, Badalona 08916, Spain
[2] Univ Catanzaro Magna Graecia, Dept Pharmacobiol Sci, Catanzaro, Italy
[3] CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain
[4] Univ Autonoma Madrid, Madrid, Spain
[5] Univ Roma Tor Vergata, Dept Expt Med, Rome, Italy
[6] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain
来源：
JOURNAL OF VIROLOGY | 2009年 / 83卷 / 15期
关键词：
RESISTANCE MUTATIONS; ANTIRETROVIRAL THERAPY; ZIDOVUDINE RESISTANCE; VIROLOGICAL RESPONSE; EXPERIENCED PATIENTS; COMBINATION THERAPY; IN-VITRO; HIV-1; PATTERNS; INHIBITORS;
D O I：
10.1128/JVI.00487-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A negative association between polymorphism Leu-214 and type-1 thymidine analogue mutations (TAM1) and a positive association with a clinically favorable virological response to thymidine analogue-based combination antiretroviral therapy have been described. In this study, the impact of Leu-214 on replication capacity and resistance to zidovudine (ZDV) of viruses containing TAM1 or TAM2 was determined. Leu-214 decreased the growth rate of viruses bearing Tyr-215, as well as their resistance to ZDV. This observation was confirmed by structural and molecular modeling data, suggesting a regulatory role for Leu-214 in the emergence and phenotypic resistance of TAM1.
引用
收藏
页码：7434 / 7439
页数：6
相关论文
共 50 条
  • [31] Combinations of Mutations in the Connection Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Assessing the Impact on Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitor Resistance
    Gupta, Soumi
    Fransen, Signe
    Paxinos, Ellen E.
    Stawiski, Eric
    Huang, Wei
    Petropoulos, Christos J.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) : 1973 - 1980
  • [32] A bioorganometallic approach for rapid electrochemical analysis of human immunodeficiency virus type-1 reverse transcriptase in serum
    Labib, Mahmoud
    Shipman, Patrick O.
    Martic, Sanela
    Kraatz, Heinz-Bernhard
    ELECTROCHIMICA ACTA, 2011, 56 (14) : 5122 - 5128
  • [33] p53 enhances the fidelity of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase
    Bakhanashvili, M
    ONCOGENE, 2001, 20 (52) : 7635 - 7644
  • [34] THE INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE BY AVAROL AND AVARONE DERIVATIVES
    LOYA, S
    HIZI, A
    FEBS LETTERS, 1990, 269 (01) : 131 - 134
  • [35] Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication
    Miller, Leia K.
    Kobayashi, Yoshifumi
    Chen, Chiann-Chyi
    Russnak, Timothy A.
    Ron, Yacov
    Dougherty, Joseph P.
    RETROVIROLOGY, 2013, 10
  • [36] Highly efficient inhibition of human immunodeficiency virus type 1 reverse transcriptase by aptamers functionalized gold nanoparticles
    Shiang, Yen-Chun
    Ou, Chung-Mao
    Chen, Shih-Ju
    Ou, Ting-Yu
    Lin, Han-Jia
    Huang, Chih-Ching
    Chang, Huan-Tsung
    NANOSCALE, 2013, 5 (07) : 2756 - 2764
  • [37] Controlling elements in replication of the human immunodeficiency virus type 1
    Li, XG
    Quan, YD
    Wainberg, MA
    CELLULAR AND MOLECULAR BIOLOGY, 1997, 43 (03) : 443 - 454
  • [38] Characterizing the antiviral effect of an ATR inhibitor on human immunodeficiency virus type 1 replication
    Docando, Felix
    Casado, Concepcion
    Pernas, Maria
    Mota-Biosca, Anna
    Lopez-Galindez, Cecilio
    Olivares, Isabel
    ARCHIVES OF VIROLOGY, 2020, 165 (03) : 683 - 690
  • [39] Human Immunodeficiency Virus Type 1 Drug Resistance Mutations Update
    Shafer, Robert W.
    JOURNAL OF INFECTIOUS DISEASES, 2017, 216 : S843 - S846
  • [40] The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase
    Gao, HQ
    Boyer, PL
    Sarafianos, SG
    Arnold, E
    Hughes, SH
    JOURNAL OF MOLECULAR BIOLOGY, 2000, 300 (02) : 403 - 418
12345