Three dimensional biphasic calcium phosphate nanocomposites for load bearing bioactive bone grafts

被引：17

作者：

Garai, Subhadra ^{[1
]}

Sinha, Arvind ^{[1
]}

机构：

[1] CSIR Nat Met Lab, Mat Sci & Technol Div, Jamshedpur 831007, Bihar, India

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 59卷

关键词：

Biphasic calcium phosphate; Calcium-deficient hydroxyapatite; Porous scaffolds; Cellulose polymer; SCAFFOLDS; COATINGS; CERAMICS; TCP;

D O I：

10.1016/j.msec.2015.10.027

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Mimicking matrix mediated bio-mineralization process, three dimensional-blocks of biphasic calcium phosphate (BCP, hydroxyapatite (HA) and beta-tricalcium phosphate (TCP)) nanocomposites, having three different stoichiometries have been synthesized for possible application as load bearing synthetic bone graft or scaffolds. Biphasic blocks with three weight ratios of 20:80, 25:75 and 30:70 of HA and TCP respectively have been synthesized. Detailed structural and chemical characterization of the samples revealed a strong dependence of porosity and mechanical properties on the stoichiometry of biphasic blocks. Effect of physiological medium on the microstructure and mechanical properties of the three different blocks has also been studied. Bioactivity of the BCP block, exhibiting highest compressive strength in air as well as in physiological medium, has been evaluated through adhesion, proliferation and differentiation of mesenchymal stem cells using different markers. (C) 2015 Elsevier BM. All rights reserved.

引用

页码：375 / 383

页数：9

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