Variations in Gene Expression and Response to Neoadjuvant Chemotherapy in Breast Carcinoma

被引：5
|
作者：
Boidot, Romain [1 ,4 ]
Vegran, Frederique [1 ,4 ]
Soubeyrand, Marie-Sophie [2 ]
Fumoleau, Pierre [3 ]
Coudert, Bruno [3 ]
Lizard-Nacol, Sarab [1 ,4 ]
机构：
[1] IFR Sante STIC, Mol Genet Lab, Ctr Georges Francois Leclerc, F-21034 Dijon, France
[2] IFR Sante STIC, Pathol Lab, F-21034 Dijon, France
[3] IFR Sante STIC, Dept Oncol, F-21034 Dijon, France
[4] IFR Sante STIC, UMR, INSERM, U866, F-21034 Dijon, France
来源：
CANCER INVESTIGATION | 2009年 / 27卷 / 05期
关键词：
Gene expression; Apoptosis; Cell cycle; Stress; Neoadjuvant chemotherapy; Breast cancer; COMPLETE PATHOLOGICAL RESPONSE; CANCER; DOCETAXEL; PROFILES; DOXORUBICIN; EPIRUBICIN; MICROARRAYS; PREDICTION; APOPTOSIS; TUMORS;
D O I：
10.1080/07357900802298096
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this study, we performed a screening of 266 gene expressions in breast carcinomas and carried out correlations with histological response to either FEC-100 (fluorouracil-epirubicin-cyclophosphamide; n = 16) or Tax-Epi (docetaxel-epirubicin; n = 12) treatment. Gene expression in biopsies obtained before and after one course of chemotherapy was analyzed. Expression of specific genes was significantly changed after one course of chemotherapy, particularly for Tax-Epi treatment. Comparison with histological response for both treatments revealed that only good responders exhibited changes in gene-expression profile. These results agree that expression of different genes changes in response to anthracycline-based neoadjuvant chemotherapy and show, for the first time, that response to docetaxel-based treatment implied also changes in gene-expression profile.
引用
收藏
页码：521 / 528
页数：8
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