Variations in Gene Expression and Response to Neoadjuvant Chemotherapy in Breast Carcinoma

被引：5
|
作者：
Boidot, Romain [1 ,4 ]
Vegran, Frederique [1 ,4 ]
Soubeyrand, Marie-Sophie [2 ]
Fumoleau, Pierre [3 ]
Coudert, Bruno [3 ]
Lizard-Nacol, Sarab [1 ,4 ]
机构：
[1] IFR Sante STIC, Mol Genet Lab, Ctr Georges Francois Leclerc, F-21034 Dijon, France
[2] IFR Sante STIC, Pathol Lab, F-21034 Dijon, France
[3] IFR Sante STIC, Dept Oncol, F-21034 Dijon, France
[4] IFR Sante STIC, UMR, INSERM, U866, F-21034 Dijon, France
来源：
CANCER INVESTIGATION | 2009年 / 27卷 / 05期
关键词：
Gene expression; Apoptosis; Cell cycle; Stress; Neoadjuvant chemotherapy; Breast cancer; COMPLETE PATHOLOGICAL RESPONSE; CANCER; DOCETAXEL; PROFILES; DOXORUBICIN; EPIRUBICIN; MICROARRAYS; PREDICTION; APOPTOSIS; TUMORS;
D O I：
10.1080/07357900802298096
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this study, we performed a screening of 266 gene expressions in breast carcinomas and carried out correlations with histological response to either FEC-100 (fluorouracil-epirubicin-cyclophosphamide; n = 16) or Tax-Epi (docetaxel-epirubicin; n = 12) treatment. Gene expression in biopsies obtained before and after one course of chemotherapy was analyzed. Expression of specific genes was significantly changed after one course of chemotherapy, particularly for Tax-Epi treatment. Comparison with histological response for both treatments revealed that only good responders exhibited changes in gene-expression profile. These results agree that expression of different genes changes in response to anthracycline-based neoadjuvant chemotherapy and show, for the first time, that response to docetaxel-based treatment implied also changes in gene-expression profile.
引用
收藏
页码：521 / 528
页数：8
相关论文
共 50 条
  • [1] Chemotherapy-induced tumor gene expression changes in human breast cancers
    Lee, Soo-Chin
    Xu, Xin
    Lim, Yi-Wan
    Lau, Philip
    Sukri, Norita
    Lim, Siew-Eng
    Yap, Hui Ling
    Yeo, Wee-Lee
    Tan, Patrick
    Tan, Sing-Huang
    McLeod, Howard
    Goh, Boon-Cher
    PHARMACOGENETICS AND GENOMICS, 2009, 19 (03): : 181 - 192
  • [2] Does Apoptotic Index Predict the Response to Neoadjuvant Chemotherapy in Patients with Breast Carcinoma?
    Askan, Gokce
    Okcu, Oguzhan
    Ozturk, Cigdem
    Ozturk, Seda Duman
    Sen, Bayram
    Bedir, Recep
    MEDENIYET MEDICAL JOURNAL, 2023, 38 (01):
  • [3] Characterizing Response to Neoadjuvant Chemotherapy in Invasive Lobular Breast Carcinoma
    Riba, Luis A.
    Russell, Teresa
    Alapati, Amulya
    Davis, Roger B.
    James, Ted A.
    JOURNAL OF SURGICAL RESEARCH, 2019, 233 : 436 - 443
  • [4] A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy
    Lin, Yiing
    Lin, Shin
    Watson, Mark
    Trinkaus, Kathryn M.
    Kuo, Sacha
    Naughton, Michael J.
    Weilbaecher, Katherine
    Fleming, Timothy P.
    Aft, Rebecca L.
    BREAST CANCER RESEARCH AND TREATMENT, 2010, 123 (03) : 691 - 699
  • [5] Predicting response of bladder cancers to gemcitabine and carboplatin neoadjuvant chemotherapy through genome-wide gene expression profiling
    Kato, Yoichiro
    Zembutsu, Hitoshi
    Takata, Ryo
    Miya, Fuyuki
    Tsunoda, Tatsuhiko
    Obara, Wataru
    Fujioka, Tomoaki
    Nakamura, Yusuke
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2011, 2 (01) : 47 - 56
  • [6] Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma
    Loibl, Sibylle
    Volz, Cristina
    Mau, Christine
    Blohmer, Jens-Uwe
    Costa, Serban D.
    Eidtmann, Holger
    Fasching, Peter A.
    Gerber, Bernd
    Hanusch, Claus
    Jackisch, Christian
    Kuemmel, Sherko
    Huober, Jens
    Denkert, Carsten
    Hilfrich, Joern
    Konecny, Gottfried E.
    Fett, Werner
    Stickeler, Elmar
    Harbeck, Nadia
    Mehta, Keyur M.
    Nekljudova, Valentina
    von Minckwitz, Gunter
    Untch, Michael
    BREAST CANCER RESEARCH AND TREATMENT, 2014, 144 (01) : 153 - 162
  • [7] Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer
    Agnieszka Kolacinska
    Wojciech Fendler
    Janusz Szemraj
    Bozena Szymanska
    Ewa Borowska-Garganisz
    Magdalena Nowik
    Justyna Chalubinska
    Robert Kubiak
    Zofia Pawlowska
    Maria Blasinska-Morawiec
    Piotr Potemski
    Arkadiusz Jeziorski
    Zbigniew Morawiec
    Molecular Biology Reports, 2012, 39 : 7435 - 7441
  • [8] Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer
    Kolacinska, Agnieszka
    Fendler, Wojciech
    Szemraj, Janusz
    Szymanska, Bozena
    Borowska-Garganisz, Ewa
    Nowik, Magdalena
    Chalubinska, Justyna
    Kubiak, Robert
    Pawlowska, Zofia
    Blasinska-Morawiec, Maria
    Potemski, Piotr
    Jeziorski, Arkadiusz
    Morawiec, Zbigniew
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (07) : 7435 - 7441
  • [9] Predicting response to docetaxel neoadjuvant chemotherapy for advanced breast cancers through genome-wide gene expression profiling
    Zembutsu, Hitoshi
    Suzuki, Yasuyo
    Sasaki, Aya
    Tsunoda, Tatsuhiko
    Okazaki, Minoru
    Yoshimoto, Masataka
    Hasegawa, Tadashi
    Hirata, Koichi
    Nakamura, Yusuke
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2009, 34 (02) : 361 - 370
  • [10] Gene expression-based diagnosis of efficacy of chemotherapy for breast cancer
    Miki, Yoshio
    BREAST CANCER, 2010, 17 (02) : 97 - 102
12345