MRI Reveals Brain Abnormalities in Drug-Naive Parkinson's Disease

被引：13
|
作者：
Planetta, Peggy J. [1 ]
McFarland, Nikolaus R. [2 ,3 ]
Okun, Michael S. [2 ,3 ,4 ]
Vaillancourt, David E. [1 ,2 ,5 ]
机构：
[1] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA
[2] Univ Florida, Dept Neurol, Gainesville, FL 32611 USA
[3] Univ Florida, Ctr Movement Disorders & Neurorestorat, Gainesville, FL 32611 USA
[4] Univ Florida, Dept Neurosurg, Gainesville, FL 32611 USA
[5] Univ Florida, Dept Biomed Engn, Gainesville, FL 32611 USA
来源：
EXERCISE AND SPORT SCIENCES REVIEWS | 2014年 / 42卷 / 01期
基金：
美国国家卫生研究院;
关键词：
diffusion tensor imaging; functional magnetic resonance imaging; fMRI; parkinsonism; grip force; subtype; de novo; movement; BASAL GANGLIA NUCLEI; SUBSTANTIA-NIGRA; FORCE AMPLITUDE; DIFFUSION; LEVODOPA; ACTIVATION; PATHOLOGY; SUBTYPES; CORTEX; FMRI;
D O I：
10.1249/JES.0000000000000003
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Most brain studies of Parkinson's disease (PD) focus on patients who are already taking antiparkinsonian medication. This makes it difficult to isolate the effects of disease from those of treatment. We review magnetic resonance imaging evidence supporting the hypothesis that early-stage untreated PD patients have structural and functional abnormalities in the brain, some of which are related to motor symptoms.
引用
收藏
页码：12 / 22
页数：11
相关论文
共 50 条
  • [41] Microstructural abnormalities of substantia nigra in Parkinson's disease: A neuromelanin sensitive MRI atlas based study
    Safai, Apoorva
    Prasad, Shweta
    Chougule, Tanay
    Saini, Jitender
    Pal, Pramod K.
    Ingalhalikar, Madhura
    HUMAN BRAIN MAPPING, 2020, 41 (05) : 1323 - 1333
  • [42] Comparison of gait parameters between drug-naive patients diagnosed with multiple system atrophy with predominant parkinsonism and Parkinson's disease
    Na, Boo Suk
    Ha, Jongmok
    Park, Ji-Hyung
    Ahn, Jong Hyeon
    Kim, Minkyeong
    Kim, Ji Sun
    Kim, Hee-Tae
    Cho, Jin Whan
    Youn, Jinyoung
    PARKINSONISM & RELATED DISORDERS, 2019, 60 : 87 - 91
  • [43] Cerebellar functional connectivity change is associated with motor and neuropsychological function in early stage drug-naive patients with Parkinson's disease
    Jiang, Li
    Zhuo, Jiachen
    Furman, Andrew
    Fishman, Paul S.
    Gullapalli, Rao
    FRONTIERS IN NEUROSCIENCE, 2023, 17
  • [44] Altered functional network topology correlates with clinical measures in very early-stage, drug-naive Parkinson's disease
    Sreenivasan, Karthik
    Mishra, Virendra
    Bird, Christopher
    Zhuang, Xiaowei
    Yang, Zhengshi
    Cordes, Dietmar
    Walsh, Ryan R.
    PARKINSONISM & RELATED DISORDERS, 2019, 62 : 3 - 9
  • [45] A Perfusion MRI Study of Emotional Valence and Arousal in Parkinson's Disease
    Limsoontarakul, Sunsern
    Campbell, Meghan C.
    Black, Kevin J.
    PARKINSONS DISEASE, 2011, 2011
  • [46] Functional MRI in Parkinson's Disease Cognitive Impairment
    Baggio, Hugo C.
    Junque, Carme
    IMAGING IN MOVEMENT DISORDERS: IMAGING IN NON-PARKINSONIAN MOVEMENT DISORDERS AND DEMENTIAS, PT 2, 2019, 144 : 29 - 58
  • [47] Differential effects of deep brain stimulation and levodopa on brain activity in Parkinson's disease
    Mueller, Karsten
    Urgosik, Dusan
    Ballarini, Tommaso
    Holiga, Stefan
    Moeller, Harald E.
    Ruzicka, Filip
    Roth, Jan
    Vymazal, Josef
    Schroeter, Matthias L.
    Ruzicka, Evzen
    Jech, Robert
    BRAIN COMMUNICATIONS, 2020, 2 (01)
  • [48] Motor Matters: Tackling Heterogeneity of Parkinson's Disease in Functional MRI Studies
    Holiga, Stefan
    Mueller, Karsten
    Moeller, Harald E.
    Sieger, Tomas
    Schroeter, Matthias L.
    Vymazal, Josef
    Ruzicka, Evzen
    Jech, Robert
    PLOS ONE, 2013, 8 (02):
  • [49] Transcriptional substrates of brain structural and functional impairments in drug-naive first-episode patients with major depressive disorder
    Fang, Qian
    Cai, Huanhuan
    Jiang, Ping
    Zhao, Han
    Song, Yu
    Zhao, Wenming
    Yu, Yongqiang
    Zhu, Jiajia
    JOURNAL OF AFFECTIVE DISORDERS, 2023, 325 : 522 - 533
  • [50] Identify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study
    Yang, Chunxia
    Zhang, Aixia
    Jia, Aixiang
    Ma, Jack X.
    Sun, Ning
    Wang, Yanfang
    Li, Xinrong
    Liu, Zhifen
    Liu, Sha
    Xu, Yong
    Zhang, Kerang
    NEUROREPORT, 2018, 29 (11) : 907 - 916
12345