The Clostridium difficile PCR ribotype 027 lineage: a pathogen on the move

被引：82

作者：

Valiente, E. ^{[1
]}

Cairns, M. D. ^{[1
,2
,3
]}

Wren, B. W. ^{[1
]}

机构：

[1] LSHTM, Dept Pathogen Mol Biol, London WC1E 7HT, England

[2] UCL, Ctr Clin Microbiol, Div Infect & Immun, London, England

[3] Royal London Hosp, Publ Hlth Lab London, Div Infect, London E1 1BB, England

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Clostridium difficile; dissemination; evolution; genome analysis; pathogen; PCR RT 027; SURFACE-LAYER PROTEINS; BINARY TOXIN; BI/NAP1/027; STRAIN; SEQUENCE-ANALYSIS; RHO-PROTEINS; EPIDEMIC; INFECTION; DISEASE; OUTBREAK; EVOLUTION;

D O I：

10.1111/1469-0691.12619

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clostridium difficile is a Gram-positive, spore-forming, human and animal pathogen that is the major cause of antibiotic-associated diarrhoea worldwide. The past decade has seen the rapid emergence of the hypervirulent PCR ribotype (RT) 027 complex, which has been associated with increases in the incidence and severity of disease and mortality. In this review, we describe the potential virulence factors that have been reported in strains from the RT 027 complex. We review the emergence, population structure, dissemination and evolution of this lineage.

引用

页码：396 / 404

页数：9

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