The Clostridium difficile PCR ribotype 027 lineage: a pathogen on the move

被引：82

作者：

Valiente, E. ^{[1
]}

Cairns, M. D. ^{[1
,2
,3
]}

Wren, B. W. ^{[1
]}

机构：

[1] LSHTM, Dept Pathogen Mol Biol, London WC1E 7HT, England

[2] UCL, Ctr Clin Microbiol, Div Infect & Immun, London, England

[3] Royal London Hosp, Publ Hlth Lab London, Div Infect, London E1 1BB, England

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Clostridium difficile; dissemination; evolution; genome analysis; pathogen; PCR RT 027; SURFACE-LAYER PROTEINS; BINARY TOXIN; BI/NAP1/027; STRAIN; SEQUENCE-ANALYSIS; RHO-PROTEINS; EPIDEMIC; INFECTION; DISEASE; OUTBREAK; EVOLUTION;

D O I：

10.1111/1469-0691.12619

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clostridium difficile is a Gram-positive, spore-forming, human and animal pathogen that is the major cause of antibiotic-associated diarrhoea worldwide. The past decade has seen the rapid emergence of the hypervirulent PCR ribotype (RT) 027 complex, which has been associated with increases in the incidence and severity of disease and mortality. In this review, we describe the potential virulence factors that have been reported in strains from the RT 027 complex. We review the emergence, population structure, dissemination and evolution of this lineage.

引用

页码：396 / 404

页数：9

共 87 条

[41] Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile [J].

Lanis, Jordi M. ;

Barua, Soumitra ;

Ballard, Jimmy D. .

PLOS PATHOGENS, 2010, 6 (08) :65-66

[42] Multilocus sequence analysis and comparative evolution of virulence-associated genes and housekeeping genes of Clostridium difficile [J].

Lemée, L ;

Bourgeois, I ;

Ruffin, E ;

Collignon, A ;

Lemeland, JF ;

Pons, JL .

MICROBIOLOGY-SGM, 2005, 151 :3171-3180

[43] Current Status of Clostridium difficile Infection Epidemiology [J].

Lessa, Fernanda C. ;

Gould, Carolyn V. ;

McDonald, L. Clifford .

CLINICAL INFECTIOUS DISEASES, 2012, 55 :S65-S70

[44] EFFECTS OF THE 2 TOXINS OF CLOSTRIDIUM-DIFFICILE IN ANTIBIOTIC-ASSOCIATED CECITIS IN HAMSTERS [J].

LIBBY, JM ;

JORTNER, BS ;

WILKINS, TD .

INFECTION AND IMMUNITY, 1982, 36 (02) :822-829

[45]

Lim PL, 2011, SINGAP MED J, V52, P361

[46] A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality [J].

Loo, VG ;

Poirier, L ;

Miller, MA ;

Oughton, M ;

Libman, MD ;

Michaud, S ;

Bourgault, AM ;

Nguyen, T ;

Frenette, C ;

Kelly, M ;

Vibien, A ;

Brassard, P ;

Fenn, S ;

Dewar, K ;

Hudson, TJ ;

Horn, R ;

René, P ;

Monczak, Y ;

Dascal, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2442-2449

[47] Host and Pathogen Factors for Clostridium difficile Infection and Colonization [J].

Loo, Vivian G. ;

Bourgault, Anne-Marie ;

Poirier, Louise ;

Lamothe, Francois ;

Michaud, Sophie ;

Turgeon, Nathalie ;

Toye, Baldwin ;

Beaudoin, Axelle ;

Frost, Eric H. ;

Gilca, Rodica ;

Brassard, Paul ;

Dendukuri, Nandini ;

Beliveau, Claire ;

Oughton, Matthew ;

Brukner, Ivan ;

Dascal, Andre .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (18) :1693-1703

[48] Spread of epidemic Clostridium difficile NAP1/027 in Latin America: case reports in Panama [J].

Lopez-Urena, Diana ;

Quesada-Gomez, Carlos ;

Miranda, Erick ;

Fonseca, Mercedes ;

Rodriguez-Cavallini, Evelyn .

JOURNAL OF MEDICAL MICROBIOLOGY, 2014, 63 :322-324

[49] CHARACTERIZATION OF TOXIN-A AND TOXIN-B OF CLOSTRIDIUM-DIFFICILE WITH MONOCLONAL-ANTIBODIES [J].

LYERLY, DM ;

PHELPS, CJ ;

TOTH, J ;

WILKINS, TD .

INFECTION AND IMMUNITY, 1986, 54 (01) :70-76

[50] Multilocus sequence typing of bacteria [J].

Maiden, Martin C. J. .

ANNUAL REVIEW OF MICROBIOLOGY, 2006, 60 :561-588

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