Cleavage of the C-C triple bond of ketoalkynes: synthesis of 4(3H)-quinazolinones

被引：102
|
作者：
Yang, Xifa [1 ,2 ,3 ]
Cheng, Guolin [1 ,2 ,3 ]
Shen, Jinhai [1 ,2 ,3 ]
Kuai, Changsheng [1 ,2 ,3 ]
Cui, Xiuling [1 ,2 ,3 ]
机构：
[1] Huaqiao Univ, Inst Mol Med, Key Lab Xiamen Marine & Gene Drugs, Xiamen 361021, Peoples R China
[2] Huaqiao Univ, Sch Biomed Sci, Xiamen 361021, Peoples R China
[3] Minist Educ, Engn Res Ctr Mol Med, Xiamen 361021, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2015年 / 2卷 / 04期
关键词：
METAL-FREE CONDITIONS; REGIOSPECIFIC SYNTHESIS; QUINAZOLINONES; CASCADE; INHIBITORS; AMIDATION; ALCOHOLS; POTENT;
D O I：
10.1039/c4qo00260a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel protocol for the synthesis of 4(3H)-quinazolinones via selective cleavage of the triple bond of ketoalkynes under oxidant-, metal-, and ligand-free conditions has been developed. Various 4(3H)-quinazolinones were obtained through fragmentation of the C-C triple bond and formation of two C-N bonds.
引用
收藏
页码：366 / 368
页数：3
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