The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products

被引：26
|
作者：
Tirabassi, RS [1 ]
Ploegh, HL [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
来源：
JOURNAL OF VIROLOGY | 2002年 / 76卷 / 13期
关键词：
D O I：
10.1128/JVI.76.13.6832-6835.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human cytomegalovirus US8 is a type I membrane protein that partially colocalizes with cellular endosomal and lysosomal proteins. Although US8 does not have discernible effects on the processing and cell surface distribution of major histocompatibility complex (MHC) class I products, we have demonstrated that US8 binds to MHC class I heavy chains in the endoplasmic reticulum.
引用
收藏
页码：6832 / 6835
页数：4
相关论文
共 50 条
  • [21] Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11 (vol 188, pg 497, 1998)
    Schust, DJ
    Tortorella, D
    Seebach, J
    Phan, C
    Bacík, I
    Bennink, JR
    Yewdell, JW
    Ploegh, HL
    JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (01): : 151 - 151
  • [22] Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection
    Terauchi, M
    Koi, H
    Hayano, C
    Toyama-Sorimachi, N
    Karasuyama, H
    Yamanashi, Y
    Aso, T
    Shirakata, M
    JOURNAL OF VIROLOGY, 2003, 77 (15) : 8187 - 8195
  • [23] Down-regulation of surface major histocompatibility complex class I by guinea pig cytomegalovirus
    Lacayo, J
    Sato, H
    Kamiya, H
    McVoy, MA
    JOURNAL OF GENERAL VIROLOGY, 2003, 84 : 75 - 81
  • [24] Human cytomegalovirus protein pp71 disrupts major histocompatibility complex class I cell surface expression
    Trgovcich, J
    Cebulla, C
    Zimmerman, P
    Sedmak, DD
    JOURNAL OF VIROLOGY, 2006, 80 (02) : 951 - 963
  • [25] THE CLASS-I AND CLASS-II PROTEINS OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX
    STROMINGER, JL
    WILEY, DC
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13): : 1074 - 1076
  • [26] CLASS-I AND CLASS-II LOCI OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX
    DYER, PA
    BAILLIERES CLINICAL RHEUMATOLOGY, 1988, 2 (03): : 529 - 546
  • [27] Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: The role of endogenous class I major histocompatibility complex and a viral class I homolog
    Leong, CC
    Chapman, TL
    Bjorkman, PJ
    Formankova, D
    Mocarski, ES
    Phillips, JH
    Lanier, LL
    JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10): : 1681 - 1687
  • [28] A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes
    Hudson, AW
    Howley, PM
    Ploegh, HL
    JOURNAL OF VIROLOGY, 2001, 75 (24) : 12347 - 12358
  • [29] A structural determinant of human cytomegalovirus US2 dictates the down-regulation of class I major histocompatibility molecules
    Oresic, Kristina
    Noriega, Vanessa
    Andrews, Laura
    Tortorella, Domenico
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (28) : 19395 - 19406
  • [30] Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation (vol 76, pg 8265, 2002)
    Chevalier, MS
    Daniels, GM
    Johnson, DC
    JOURNAL OF VIROLOGY, 2002, 76 (24) : 13126 - 13126
12345