The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products

被引：26
|
作者：
Tirabassi, RS [1 ]
Ploegh, HL [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
来源：
JOURNAL OF VIROLOGY | 2002年 / 76卷 / 13期
关键词：
D O I：
10.1128/JVI.76.13.6832-6835.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human cytomegalovirus US8 is a type I membrane protein that partially colocalizes with cellular endosomal and lysosomal proteins. Although US8 does not have discernible effects on the processing and cell surface distribution of major histocompatibility complex (MHC) class I products, we have demonstrated that US8 binds to MHC class I heavy chains in the endoplasmic reticulum.
引用
收藏
页码：6832 / 6835
页数：4
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