Urothelial carcinoma of the renal pelvis with rhabdoid features

被引：13

作者：

Fukumura, Yuki ^{[1
]}

Fujii, Hiroaki ^{[2
]}

Mitani, Keiko

Sakamoto, Yoshiro ^{[3
]}

Matsumoto, Toshiharu

Suda, Koichi ^{[4
]}

Yao, Takashi

机构：

[1] Juntendo Univ, Dept Human Pathol, Sch Med, Bunkyo Ku, Tokyo 1538421, Japan

[2] Juntendo Univ, Dept Pathol & Tumors, Sch Med, Tokyo 1538421, Japan

[3] Juntendo Univ, Dept Urol, Sch Med, Tokyo 1538421, Japan

[4] Tokyo W Tokushukai Hosp, Dept Pathol, Tokyo, Japan

来源：

PATHOLOGY INTERNATIONAL | 2009年 / 59卷 / 05期

关键词：

clonality; loss of heterozygosity; renal pelvis; rhabdoid; urothelial carcinoma; URINARY-BLADDER; CELL; CARCINOSARCOMA; HISTOGENESIS;

D O I：

10.1111/j.1440-1827.2009.02373.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Reported herein is the case of a 70-year-old man with high grade urothelial carcinoma (UC) with rhabdoid features of the renal pelvis. For the most part, the tumor was composed of pleomorphic, non-cohesive round tumor cells with abundant cytoplasm. In situ high-grade UC composed of cohesive tumor cells was seen only in a small portion. Pleomorphic dyscohesive tumor cells often showed rhabdoid features, containing eosinophilic inclusions. These pleomorphic/rhabdoid tumor cells were immunohistochemically positive for vimentin but negative for cytokeratins, CD45, CD20, CD79a, CD3, CD45RO, CD38, and CD138. Loss of heterozygosity (LOH) analysis demonstrated identical allelic losses as well as additional allelic losses for the dyscohesive and cohesive UC lesion, indicating that these two lesions originated from a single clonal lesion.

引用

页码：322 / 325

页数：4

共 12 条

[1] BLADDER CARCINOSARCOMAS - 3 CASES WITH DIVERSE HISTOGENESIS [J].