Protein/carbon nanotubes interaction: The effect of carboxylic groups on conformational and conductance changes

被引：34

作者：

Wijaya, I. Putu Mahendra ^{[2
,4
]}

Gandhi, Sonu

Nie, Tey Ju ^{[2
]}

Wangoo, Nishima ^{[1
]}

Rodriguez, Isabel ^{[4
]}

Shekhawat, G. ^{[3
]}

Suri, C. Raman ^{[1
]}

Mhaisalkar, Subodh G. ^{[2
]}

机构：

[1] Inst Microbial Technol, Chandigarh 160036, India

[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

[3] Northwestern Univ, Inst Nanotechnol, Evanston, IL 60208 USA

[4] Inst Mat Res & Engn, Singapore 117602, Singapore

来源：

APPLIED PHYSICS LETTERS | 2009年 / 95卷 / 07期

关键词：

biochemistry; bioelectric phenomena; biosensors; carbon nanotubes; molecular biophysics; molecular configurations; proteins; CARBON NANOTUBES; TRANSISTORS;

D O I：

10.1063/1.3211328

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Detailed understanding of interaction between biomolecules and single-walled carbon nanotubes (SWCNTs) is important in the design and applications of biosensors that employ SWCNTs for transduction of the analytes response. Reciprocal interactions of SWCNT with bovine serum albumin are investigated here with pristine and carboxylated nanotubes. Carboxylic functionalization was found to inflict a deeper change on protein conformation, than their pristine counterparts, accompanied with a change in nanotube conductance. This observation has significant implications for biosensors in highlighting the need to take into account the surface functionalization state of the active materials.

引用

页数：3

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