The clinical application of gene editing: ethical and social issues

被引：24

作者：

Ormond, Kelly E. ^{[1
,2
]}

Bombard, Yvonne ^{[3
,4
]}

Bonham, Vence L. ^{[5
]}

Hoffman-Andrews, Lily ^{[6
]}

Howard, Heidi ^{[7
,8
]}

Isasi, Rosario ^{[9
]}

Musunuru, Kiran ^{[10
]}

Riggan, Kirsten A. ^{[11
]}

Michie, Marsha ^{[12
]}

Allyse, Megan ^{[11
,13
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Stanford Ctr Biomed Eth, Stanford, CA 94305 USA

[3] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

[4] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

[5] NHGRI, Social & Behav Res Branch, NIH, Bethesda, MD 20892 USA

[6] Penn Med, Penn Ctr Inherited Cardiac Dis, Philadelphia, PA 19104 USA

[7] Uppsala Univ, Ctr Res Eth & Bioeth, Uppsala, Sweden

[8] Wellcome Genome Campus, Connecting Sci, Soc & Eth Res, Cambridge, England

[9] Univ Miami, Miller Sch Med, Dr JT Macdonald Fdn, Inst Bioeth & Hlth Policy,Dept Human Genet, Miami, FL 33136 USA

[10] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[11] Mayo Clin, Biomed Eth Res Program, Rochester, MN 55905 USA

[12] Case Western Reserve Univ, Sch Med, Dept Bioeth, Cleveland, OH 44106 USA

[13] Mayo Clin, Ctr Individualized Med, Rochester, MN 55905 USA

来源：

PERSONALIZED MEDICINE | 2019年 / 16卷 / 04期

基金：

瑞典研究理事会; 加拿大健康研究院;

关键词：

clinical trials; CRISPR; ethics; gene editing; genome editing; germline gene editing; professional attitudes; public attitudes; somatic gene editing; stakeholder research; HEALTH TECHNOLOGY-ASSESSMENT; DOWN-SYNDROME PERSPECTIVES; ONE-STEP GENERATION; GENOME; ATTITUDES; THERAPY; EXPERIENCES; ENGAGEMENT; IDENTITY; SCIENCE;

D O I：

10.2217/pme-2018-0155

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gene-editing techniques have progressed rapidly in the past 5years. There are already ongoing human somatic gene-editing clinical trials for multiple diseases. And there has been one purported scenario of human germline gene editing in late 2018. In this paper, we will review the current state of the technology, discuss the ethical and social issues that surround the various forms of gene editing, as well as review emerging stakeholder data from professionals, the general public' and individuals and families dealing with genetic diseases potentially treatable by gene editing.

引用

页码：337 / 350

页数：14

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