Rapid and Scalable Access into Strained Scaffolds through Continuous Flow Photochemistry

被引：27
作者：
Blanco-Ania, Daniel [1 ]
Gawade, Sagar Ashok [1 ]
Zwinkels, Luc J. L. [1 ]
Maartense, Luuk [1 ]
Bolster, Marjon G. [2 ]
Benningshof, Jorg C. J. [2 ]
Rutjes, Floris P. J. T. [1 ]
机构：
[1] Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands
[2] Mercachem BV, Kerkenbos 1013, NL-6546 BB Nijmegen, Netherlands
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2016年 / 20卷 / 02期
关键词：
INTRAMOLECULAR PHOTOCYCLOADDITION REACTIONS; MICROREACTOR;
D O I：
10.1021/acs.oprd.5b00354
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two conformationally restricted three-dimensional aminoketone scaffolds have been synthesized in only three steps, using a continuous flow photochemistry approach, which is also amenable to scale-up. In addition, several approaches to further derivatize these scaffolds for the synthesis of low molecular weight compound libraries have been detailed.
引用
收藏
页码：409 / 413
页数：5
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