Catalytic peptide assemblies

被引:189
|
作者
Zozulia, O. [1 ]
Dolan, M. A. [1 ]
Korendovych, I. V. [1 ]
机构
[1] Syracuse Univ, Dept Chem, 111 Coll Pl, Syracuse, NY 13244 USA
关键词
ASYMMETRIC ALDOL REACTION; HIGH-RESOLUTION STRUCTURE; 4-HELIX BUNDLE CATALYSTS; P-NITROPHENYL ESTERS; BETA-SHEET PEPTIDES; LOOP-HELIX MOTIFS; DE-NOVO DESIGN; L-PROLINE; TRANSESTERIFICATION REACTIONS; COMPUTATIONAL DESIGN;
D O I
10.1039/c8cs00080h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Self-assembly of molecules often results in new emerging properties. Even very short peptides can self-assemble into structures with a variety of physical and structural characteristics. Remarkably, many peptide assemblies show high catalytic activity in model reactions reaching efficiencies comparable to those found in natural enzymes by weight. In this review, we discuss different strategies used to rationally develop self-assembled peptide catalysts with natural and unnatural backbones as well as with metal-containing cofactors.
引用
收藏
页码:3621 / 3639
页数:19
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