Biological Resistance of Hydroxychloroquine for Plasmodium vivax Malaria in the Republic of Korea

被引：14

作者：

Lee, Sei Won ^{[2
]}

Lee, Minhee ^{[3
]}

Lee, Dae Dong ^{[4
]}

Kim, Changsoo ^{[5
]}

Kim, Yeon-Joo

Kim, Jung-Yeon ^{[6
]}

Green, Michael D.

Klein, Terry A. ^{[7
]}

Kim, Heung Chul ^{[8
]}

Nettey, Henry

Ko, Dong Hoon ^{[10
]}

Kim, Hyungsuk ^{[9
]}

Park, Inho ^{[1
]}

机构：

[1] Armed Forces Seoul Hosp, Profess Serv, Seoul 110200, South Korea

[2] Armed Forces Capital Hosp, Dept Internal Med, Songnam 463040, Gyeonggi Do, South Korea

[3] Armed Forces Ildong Hosp, Dept Internal Med, Pocheon Si 487840, Gyeonggi Do, South Korea

[4] Armed Forces Yangju Hosp, Dept Lab Med, Yangju 482863, South Korea

[5] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul 120752, South Korea

[6] Korea Ctr Dis Control & Prevent, Div Malaria & Parasit Dis, NIH, Seoul 122701, South Korea

[7] USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Med Brigade 65, Unit 15281, APO, AP 96205 USA

[8] 65th Med Brigade, Multifunct Med Battal 168, Med Detachment 5, Unit 15247, APO, AP 96205 USA

[9] Armed Forces Byuck Je Hosp, Dept Clin Pathol, Goyang 412779, South Korea

[10] Armed Forces Capital Hosp, Dept Internal Med, Songnam 463040, Gyeonggi Do, South Korea

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 81卷 / 04期

关键词：

IRIAN-JAYA; CHLOROQUINE; PROPHYLAXIS; PRIMAQUINE; FALCIPARUM; DESETHYLCHLOROQUINE; CHEMOPROPHYLAXIS; MEFLOQUINE; DIAGNOSIS; TRAVELERS;

D O I：

10.4269/ajtmh.2009.09-0102

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The Republic of Korea (ROK) Army instituted a vivax malaria chemoprophylaxis program (hydroxychloroquine [HCQ] 400 mg per week) in 1997 that was expanded to nearly 200,000 soldiers by 2007, raising concerns for the emergence of drug-resistant vivax malaria. Therefore, a study of whole blood HCQ concentrations for all malaria patients admitted to four ROK Army hospitals was conducted from June through September 2007. For all 142 vivax malaria patients enrolled, fevers returned to normal by Day 3 post-treatment and all thin blood films were negative for parasites by Day 7. Pre-treatment whole blood concentrations of HCQ for 14 patients were > 100 ng/mL. Eight of the patients were enrolled in the ROK Army chemoprophylaxis program that reported taking HCQ as directed, with the last pill taken >= 4 days before diagnosis. Although there was no evidence of clinical resistance, chemoprophylaxis data indicates the biological resistance or tolerance to HCQ in ROK.

引用

页码：600 / 604

页数：5

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