Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles

被引：33
作者：
Garuti, L
Roberti, M
De Clercq, E
机构：
[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy
[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 19期
关键词：
D O I：
10.1016/S0960-894X(02)00535-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some benzimidazolyl sulphones were synthesized and evaluated for their antiviral and antiproliferative properties. Compound 10 displayed significant and selective activity against human cytomegalovirus (CMV), compound 14 showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives. Some structure-activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：2707 / 2710
页数：4
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