In vivo study of osteogenerating properties of calcium-phosphate coating on titanium alloy Ti-6Al-4V

被引：15
作者：
Gnedenkov, Sergey V. [1 ]
Sinebryukhov, Sergey L. [1 ]
Puz, Artyom V. [1 ]
Egorkin, Vladimir S. [1 ]
Kostiv, Roman E. [2 ]
机构：
[1] Russian Acad Sci, Inst Chem, Far Eastern Branch, 159 Prosp 100 Letiya Vladivostoka, Vladivostok 690022, Russia
[2] Pacific State Med Univ, 2 Prosp Ostryakova, Vladivostok, Russia
来源：
BIO-MEDICAL MATERIALS AND ENGINEERING | 2016年 / 27卷 / 06期
基金：
俄罗斯科学基金会;
关键词：
Calcium-phosphate coatings; titanium alloy Ti-6Al-4V; plasma electrolytic oxidation; implant; osteogenesis; IMPLANT APPLICATIONS; HYDROXYAPATITE; RELEASE; METAL; BIOCOMPATIBILITY; BIOMATERIALS; FABRICATION; COMPOSITE; OXIDATION;
D O I：
10.3233/BME-161608
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The method of formation of bioactive calcium-phosphate coating on medical titanium alloy Ti-6Al-4V (3.5-5.3% V; 5.3-6.8% Al; balance-Ti) by plasma electrolytic oxidation (PEO) has been developed. Evaluation of osteogenerating properties of the coating at fractures of the shaft of the femur on Wistar line laboratory rats has been performed. It has been established that the calcium-phosphate PEO coating accelerates osteogenesis and promotes the formation of a pronounced periosteal callus in the fracture area. The presence of calcium phosphates in the PEO coating surface layer significantly accelerates the growth of bone tissue on the titanium surface.
引用
收藏
页码：551 / 560
页数：10
相关论文
共 26 条
  • [1] Biocompatibility of antibacterial Ti-Cu sintered alloy: in vivo bone response
    Bai, Bing
    Zhang, Erlin
    Dong, Hui
    Liu, Jie
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2015, 26 (12)
  • [2] Cytocompatibility of Ti-6Al-4V and Ti-5Al-2.5Fe alloys according to three surface treatments, using human fibroblasts and osteoblasts
    Bordji, K
    Jouzeau, JY
    Mainard, D
    Payan, E
    Netter, P
    Rie, KT
    Stucky, T
    HageAli, M
    [J]. BIOMATERIALS, 1996, 17 (09) : 929 - 940
  • [3] Effects of surface treatment of Ti-6Al-4V titanium alloy on biocompatibility in cultured human umbilical vein endothelial cells
    Bruni, S
    Martinesi, M
    Stio, M
    Treves, C
    Bacci, T
    Borgioli, F
    [J]. ACTA BIOMATERIALIA, 2005, 1 (02) : 223 - 234
  • [4] INCREASING OF THE CORROSION-RESISTANCE OF THE TI6AL4V ALLOY BY HIGH THICKNESS ANODIC-OXIDATION
    CIGADA, A
    CABRINI, M
    PEDEFERRI, P
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1992, 3 (06) : 408 - 412
  • [5] Mechanical properties of calcium phosphate coatings deposited by laser ablation
    Clèries, L
    Martínez, E
    Fernández-Pradas, JM
    Sardin, C
    Esteve, J
    Morenza, JL
    [J]. BIOMATERIALS, 2000, 21 (09) : 967 - 971
  • [6] PLASMA SPRAYED COATINGS OF HYDROXYLAPATITE
    DEGROOT, K
    GEESINK, R
    KLEIN, CPAT
    SEREKIAN, P
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1987, 21 (12): : 1375 - 1381
  • [7] Biomaterials for dental implants: current and future trends
    Duraccio, Donatella
    Mussano, Federico
    Faga, Maria Giulia
    [J]. JOURNAL OF MATERIALS SCIENCE, 2015, 50 (14) : 4779 - 4812
  • [8] Gnedenkov S., 2013, COMPOSITE MULTIFUNCT
  • [9] Composite hydroxyapatite-PTFE coatings on Mg-Mn-Ce alloy for resorbable implant applications via a plasma electrolytic oxidation-based route
    Gnedenkov, S. V.
    Sinebryukhov, S. L.
    Zavidnaya, A. G.
    Egorkin, V. S.
    Puz, A. V.
    Mashtalyar, D. V.
    Sergienko, V. I.
    Yerokhin, A. L.
    Matthews, A.
    [J]. JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 2014, 45 (06) : 3104 - 3109
  • [10] Gnedenkov S.V., 2012, Pac. Med. J., P12
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