The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression

被引：2
|
作者：
Huang, Yong [1 ]
Zhang, KeWei [2 ]
Li, Yinghua [1 ]
Dai, Yuyin [1 ]
Zhao, Hongguang [1 ]
机构：
[1] First Hosp Jilin Univ, Dept Nucl Med, Changchun 130021, Peoples R China
[2] First Hosp Jilin Univ, Dept Thorac Surg, Changchun 130021, Peoples R China
来源：
AGING-US | 2020年 / 12卷 / 22期
关键词：
papillary thyroid cancer; DLG1-AS1; miR-497; YAP1; lncRNA; LONG NONCODING RNAS; PROLIFERATION; CARCINOMA; MIGRATION; INVASION; GROWTH;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The long non-coding RNA (lncRNA), DLG1-AS1, is upregulated in papillary thyroid cancer (PTC) tissues and cell lines. Here, we found that increased expression of DLG1-AS1 caused lymph node metastasis and advanced tumor-node-metastasis (TNM) stage. DLG1-AS1 knockdown inhibited proliferation, invasion, and migration of PTC cells, and impaired tumorigenesis in vivo in mouse xenografts. DLG1-AS1 functions as a competing endogenous RNA (ceRNA) for miR-497. Further investigation revealed that DLG1-AS1 regulated yes-associated protein 1 (YAP1; a known target of miR-497) by competitively binding to miR-497. Moreover, inhibition of miR497 abrogated the inhibitory effects of DLG1-AS1 depletion on PTC cells. These findings demonstrate that the DLG1-AS1-miR-497-YAP1 axis promotes the growth and metastasis of PTC by forming a ceRNA network.
引用
收藏
页码：23326 / 23336
页数：11
相关论文
共 50 条
  • [41] Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis
    Haojie Wu
    Weihua Li
    Shutao Zhu
    Dengfeng Zhang
    Minghui Zhang
    Cancer Cell International, 20
  • [42] LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis
    Lu, Mingming
    Gao, Qing
    Wang, Yafei
    Ren, Jie
    Zhang, Tingting
    APOPTOSIS, 2022, 27 (11-12) : 800 - 811
  • [43] Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis
    Wu, Haojie
    Li, Weihua
    Zhu, Shutao
    Zhang, Dengfeng
    Zhang, Minghui
    CANCER CELL INTERNATIONAL, 2020, 20 (01)
  • [44] miR-195 inhibits esophageal cancer cell proliferation and promotes apoptosis by downregulating YAP1
    Gao, Xinyue
    Lu, Mingjun
    Xu, Weijuan
    Liu, Centao
    Wu, Jianping
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2019, 12 (01): : 275 - 281
  • [45] PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis
    Wang, Y.
    Justilien, V.
    Brennan, K. I.
    Jamieson, L.
    Murray, N. R.
    Fields, A. P.
    ONCOGENE, 2017, 36 (04) : 534 - 545
  • [46] RBM12 regulates the progression of hepatocellular cancer via miR-497-5p/CPNE1 Axis
    Gao, Cheng
    Zhu, Renfei
    Shen, Jianbo
    Xu, Tianxin
    She, Yongjun
    Chen, Zhong
    ENVIRONMENTAL RESEARCH, 2023, 239
  • [47] YAP1 Regulates the YAP1/AR/PSA Axis through Autophagy in Castration-Resistant Prostate Cancer and Mediates T-Cell Immune and Inflammatory Cytokine Infiltration
    Wang, Youzhi
    Wu, Ning
    Li, Junbo
    Zhou, Diansheng
    Liang, Jiaming
    Cao, Qian
    Guan, Zhaokai
    Xu, Yangyang
    Jiang, Ning
    BIOMEDICINES, 2024, 12 (03)
  • [48] RETRACTED ARTICLE: Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375/YAP1 axis
    Huan Yan
    Hong Li
    Pengyun Li
    Xia Li
    Jianjian Lin
    Linlin Zhu
    Maria A. Silva
    Xiaofang Wang
    Ping Wang
    Zhan Zhang
    Journal of Experimental & Clinical Cancer Research, 37
  • [49] Asiaticoside inhibits breast cancer progression and tumor angiogenesis via YAP1/VEGFA signal pathway
    Guo, Mengmeng
    Ying, Yu
    Chen, Yun
    Miao, Xian
    Yu, Zhenghong
    HELIYON, 2024, 10 (18)
  • [50] PDZK1 Interacting Protein 1 Promotes the Progression of Papillary Thyroid Cancer
    Wang, Kun
    Liu, Shiyang
    Tian, Yao
    Liu, Chenguang
    Gui, Zhengwei
    Yu, Tianyao
    Zhang, Lin
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 107 (09) : 2449 - 2461
12345