The DLG1-AS1/miR-497/YAP1 axis regulates papillary thyroid cancer progression

被引：2
|
作者：
Huang, Yong [1 ]
Zhang, KeWei [2 ]
Li, Yinghua [1 ]
Dai, Yuyin [1 ]
Zhao, Hongguang [1 ]
机构：
[1] First Hosp Jilin Univ, Dept Nucl Med, Changchun 130021, Peoples R China
[2] First Hosp Jilin Univ, Dept Thorac Surg, Changchun 130021, Peoples R China
来源：
AGING-US | 2020年 / 12卷 / 22期
关键词：
papillary thyroid cancer; DLG1-AS1; miR-497; YAP1; lncRNA; LONG NONCODING RNAS; PROLIFERATION; CARCINOMA; MIGRATION; INVASION; GROWTH;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The long non-coding RNA (lncRNA), DLG1-AS1, is upregulated in papillary thyroid cancer (PTC) tissues and cell lines. Here, we found that increased expression of DLG1-AS1 caused lymph node metastasis and advanced tumor-node-metastasis (TNM) stage. DLG1-AS1 knockdown inhibited proliferation, invasion, and migration of PTC cells, and impaired tumorigenesis in vivo in mouse xenografts. DLG1-AS1 functions as a competing endogenous RNA (ceRNA) for miR-497. Further investigation revealed that DLG1-AS1 regulated yes-associated protein 1 (YAP1; a known target of miR-497) by competitively binding to miR-497. Moreover, inhibition of miR497 abrogated the inhibitory effects of DLG1-AS1 depletion on PTC cells. These findings demonstrate that the DLG1-AS1-miR-497-YAP1 axis promotes the growth and metastasis of PTC by forming a ceRNA network.
引用
收藏
页码：23326 / 23336
页数：11
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