Association between promoter polymorphisms of OPN gene and cancer risk: a meta-analysis

被引:4
作者
Liu, Jingwei [1 ,2 ]
He, Caiyun [1 ,2 ]
Yuan, Quan [1 ,2 ]
Wang, Zhenning [1 ,2 ]
Xing, Chengzhong [1 ,2 ]
Yuan, Yuan [1 ,2 ]
机构
[1] China Med Univ, Affiliated Hosp 1, Tumor Etiol & Screening Dept, Canc Inst & Gen Surg, Shenyang 110001, Liaoning Provin, Peoples R China
[2] China Med Univ, Liaoning Prov Educ Dept, Key Lab Canc Etiol & Prevent, Shenyang 110001, Peoples R China
关键词
OPN; promoter; polymorphism; cancer; OSTEOPONTIN; EXPRESSION; SUSCEPTIBILITY; TRANSCRIPTION; BINDING;
D O I
10.2147/OTT.S94606
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: Results of the association between polymorphisms of osteopontin (OPN) gene promoter region and risk of cancer were inconclusive. The aim of this meta-analysis was to elucidate whether OPN promoter polymorphisms were associated with cancer risk. Methods: Electronic databases including PubMed, Web of Science, and Chinese National Knowledge Infrastructure were systematically searched. Odd ratios (ORs) and their 95% confidential interval (CI) were used to assess the strength of association between OPN promoter polymorphisms and cancer risks. Results: Nine studies were finally included in this meta-analysis. For OPN rs17524488 polymorphism, carriers of GG or -/G genotype were significantly associated with increased cancer risk compared with wild-type -/-carriers, respectively (GG vs -/-: OR =1.40, 95% CI =1.03-1.91, P=0.033; -/G vs -/-: OR =1.22, 95% CI =1.07-1.40, P=0.002). Additionally, G allele was significantly associated with increased cancer risk compared with (-) allele (OR =1.21, 95% CI =1.04-1.40, P=0.016). However, no significant association was observed of OPN rs11730582 polymorphism and cancer risk (CC vs TT: OR =0.98, 95% CI =0.49-1.97, P=0.964; CT vs TT: OR =0.88, 95% CI =0.54-1.43, P=0.610). Conclusion: Carriers of GG or -/G genotype of OPN promoter rs17524488 (-156-/G) polymorphism might be associated with increased risk of cancer compared with wild-type -/-carriers, respectively. However, no significant association was observed between OPN promoter rs11730582 (-443C/T) polymorphism and risk of cancer.
引用
收藏
页码:87 / 97
页数:11
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