Highly selective oligonucleotide-based sensor for mercury(II) in aqueous solutions

被引：1144
作者：
Ono, A [1 ]
Togashi, H [1 ]
机构：
[1] Tokyo Metropolitan Univ, Grad Sch Sci, Dept Chem, Hachioji, Tokyo 1920397, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 33期
关键词：
biosensors; fluorescence; FRET (fluorescence resonance energy transfer); mercury; oligonucleotides;
D O I：
10.1002/anie.200454172
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mercury gauge: An oligodeoxyribonucleotide(ODN)-based sensor, which carries energy-donor and -acceptor moieties (fluorescein, F, and dabcyl, D, respectively), selectively detects HgII ions in aqueous solution. Upon binding HgII ions, the ODN takes on a hairpin structure (see picture); this results in a decrease in the fluorescence emission through enhanced FRET (fluorescence resonance energy transfer) from F to D.
引用
收藏
页码：4300 / 4302
页数：3
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